PMID- 25903950
OWN - NLM
STAT- MEDLINE
DCOM- 20160112
LR  - 20220330
IS  - 1899-1505 (Electronic)
IS  - 0867-5910 (Linking)
VI  - 66
IP  - 2
DP  - 2015 Apr
TI  - Effect of vitamin E on cerebral cortical oxidative stress and brain-derived 
      neurotrophic factor gene expression induced by hypoxia and exercise in rats.
PG  - 191-202
AB  - Brain-derived neurotrophic factor (BDNF) is involved in the proliferation of 
      neurons, and its expression increases significantly with exercise. We aimed to 
      investigate the effects of chronic exercise (swimming) and sustained hypoxia on 
      cortical BDNF expression in both the presence and absence of vitamin E. Sixty 
      four male Sprague-Dawley rats were divided into two equal groups; a normoxic 
      group and a hypoxic group. Both groups were equally subdivided into four 
      subgroups: sedentary, sedentary with vitamin E, chronic exercise either with or 
      without vitamin E supplementation. Arterial PO(2), and the levels of cortical 
      malondialdehyde (MDA), antioxidants (reduced glutathione GSH, superoxide 
      dismutase (SOD), catalase (CAT) and vitamin E) and BDNF gene expression were 
      investigated. Hypoxia significantly increased MDA production and BDNF gene 
      expression and decreased the antioxidants compared to control rats. Chronic 
      exercise in hypoxic and normoxic rats increased MDA level and BDNF gene 
      expression and decreased the antioxidants. Providing vitamin E supplementation to 
      the hypoxic and normoxic rats significantly reduced MDA and BDNF gene expression 
      and increased antioxidants. We conclude that sustained hypoxia and chronic 
      exercise increased BDNF gene expression and induced oxidative stress. Moreover, 
      vitamin E attenuated the oxidative stress and decreased BDNF gene expression in 
      sustained hypoxia and chronic exercise which confirms the oxidative 
      stress-induced stimulation of BDNF gene expression.
FAU - Sakr, H F
AU  - Sakr HF
AD  - Medical Physiology Department, Faculty of Medicine, Mansoura University, 
      Mansoura, Egypt. sakr_doctor@yahoo.com.
FAU - Abbas, A M
AU  - Abbas AM
FAU - El Samanoudy, A Z
AU  - El Samanoudy AZ
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 1406-18-4 (Vitamin E)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Gene Expression/*drug effects/genetics
MH  - Hypoxia/metabolism/*physiopathology
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress/*drug effects/genetics
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Swimming/physiology
MH  - Vitamin E/*administration & dosage
EDAT- 2015/04/24 06:00
MHDA- 2016/01/13 06:00
CRDT- 2015/04/24 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2015/02/09 00:00 [accepted]
PHST- 2015/04/24 06:00 [entrez]
PHST- 2015/04/24 06:00 [pubmed]
PHST- 2016/01/13 06:00 [medline]
PST - ppublish
SO  - J Physiol Pharmacol. 2015 Apr;66(2):191-202.