PMID- 25904345
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20210218
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 21
IP  - 4
DP  - 2016 Jul
TI  - Effects of drugs of abuse on the central neuropeptide Y system.
PG  - 755-65
LID - 10.1111/adb.12250 [doi]
AB  - Neuropeptide Y (NPY), which is widely expressed in the central nervous system is 
      involved in several neuropathologies including addiction. Here we comprehensively 
      and systematically review alterations on the central NPY system induced by 
      several drugs. We report on the effects of psychostimulants [cocaine, 
      amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 
      nicotine], ethanol, and opioids on NPY protein levels and expression of different 
      NPY receptors. Overall, expression and function of NPY and its receptors are 
      changed under conditions of drug exposure, thus affecting several physiologic 
      behaviors, such as feeding, stress and anxiety. Drugs of abuse differentially 
      affect the components of the NPY system. For example methamphetamine and nicotine 
      lead to a consistent increase in NPY mRNA and protein levels in different brain 
      sites whereas ethanol and opioids decrease NPY mRNA and protein expression. 
      Drug-induced alterations on the different NPY receptors show more complex 
      regulation pattern. Manipulation of the NPY system can have opposing effects on 
      reinforcing and addictive properties of drugs of abuse. NPY can produce 
      pro-addictive effects (nicotine and heroin), but can also exert inhibitory 
      effects on addictive behavior (AMPH, ethanol). Furthermore, NPY can act as a 
      neuroprotective agent in chronically methamphetamine and MDMA-treated rodents. In 
      conclusion, manipulation of the NPY system seems to be a potential target to 
      counteract neural alterations, addiction-related behaviors and cognitive deficits 
      induced by these drugs.
CI  - (c) 2015 Society for the Study of Addiction.
FAU - Goncalves, Joana
AU  - Goncalves J
AD  - Institute of Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, 
      Portugal.
AD  - Institute for Biomedical Imaging and Life Sciences (IBILI), University of 
      Coimbra, Portugal.
AD  - Center for Neuroscience and Cell Biology-Institute for Biomedical Imaging and 
      Life Sciences (CNC.IBILI) Research Unit, University of Coimbra, Portugal.
FAU - Martins, Joao
AU  - Martins J
AD  - Institute for Biomedical Imaging and Life Sciences (IBILI), University of 
      Coimbra, Portugal.
AD  - Center for Neuroscience and Cell Biology-Institute for Biomedical Imaging and 
      Life Sciences (CNC.IBILI) Research Unit, University of Coimbra, Portugal.
AD  - Centre of Ophthalmology and Vision Sciences, Faculty of Medicine, University of 
      Coimbra, Portugal.
FAU - Baptista, Sofia
AU  - Baptista S
AD  - Institute for Biomedical Imaging and Life Sciences (IBILI), University of 
      Coimbra, Portugal.
AD  - Center for Neuroscience and Cell Biology-Institute for Biomedical Imaging and 
      Life Sciences (CNC.IBILI) Research Unit, University of Coimbra, Portugal.
AD  - Laboratory of Pharmacology and Experimental Therapeutics, Faculty of Medicine, 
      University of Coimbra, Portugal.
FAU - Ambrosio, Antonio Francisco
AU  - Ambrosio AF
AD  - Institute for Biomedical Imaging and Life Sciences (IBILI), University of 
      Coimbra, Portugal.
AD  - Center for Neuroscience and Cell Biology-Institute for Biomedical Imaging and 
      Life Sciences (CNC.IBILI) Research Unit, University of Coimbra, Portugal.
AD  - Centre of Ophthalmology and Vision Sciences, Faculty of Medicine, University of 
      Coimbra, Portugal.
AD  - Association for Innovation and Biomedical Research on Light and Image (AIBILI), 
      Portugal.
FAU - Silva, Ana Paula
AU  - Silva AP
AD  - Institute for Biomedical Imaging and Life Sciences (IBILI), University of 
      Coimbra, Portugal.
AD  - Center for Neuroscience and Cell Biology-Institute for Biomedical Imaging and 
      Life Sciences (CNC.IBILI) Research Unit, University of Coimbra, Portugal.
AD  - Laboratory of Pharmacology and Experimental Therapeutics, Faculty of Medicine, 
      University of Coimbra, Portugal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150422
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Amphetamines)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Opiate Alkaloids)
RN  - 0 (Receptors, Neuropeptide Y)
RN  - 3K9958V90M (Ethanol)
RN  - 6M3C89ZY6R (Nicotine)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
EIN - Addict Biol. 2017 May;22(3):882. PMID: 28398010
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Brain/drug effects
MH  - Cocaine/*pharmacology
MH  - Disease Models, Animal
MH  - Ethanol/*pharmacology
MH  - Mice
MH  - Neuropeptide Y/*drug effects
MH  - Nicotine/*pharmacology
MH  - Opiate Alkaloids/*pharmacology
MH  - Rats
MH  - Receptors, Neuropeptide Y/drug effects
OTO - NOTNLM
OT  - Addiction
OT  - ethanol
OT  - neuropeptide Y
OT  - neuroprotection
OT  - neurotoxicity
OT  - opioids
OT  - psychostimulants
EDAT- 2015/04/24 06:00
MHDA- 2018/01/30 06:00
CRDT- 2015/04/24 06:00
PHST- 2015/04/24 06:00 [entrez]
PHST- 2015/04/24 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
AID - 10.1111/adb.12250 [doi]
PST - ppublish
SO  - Addict Biol. 2016 Jul;21(4):755-65. doi: 10.1111/adb.12250. Epub 2015 Apr 22.