PMID- 25905038
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150423
LR  - 20220330
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 5
DP  - 2015
TI  - Metastatic non-clear cell renal cell carcinoma: an evidence based review of 
      current treatment strategies.
PG  - 67
LID - 10.3389/fonc.2015.00067 [doi]
LID - 67
AB  - Much progress has been made in the treatment of metastatic renal cell carcinoma 
      (RCC) over the last decade, with the development of agents that block the 
      vascular endothelial growth factor (VEGF) pathway or the mammalian target of 
      rapamycin (mTOR) pathway. The incorporation of these agents into treatment 
      algorithms has been the result of carefully conducted clinical trials leading to 
      Food and Drug Administration (FDA) approval and subsequent adoption as the 
      current standard of care. These trials, however, were dominated by patients with 
      clear cell renal cell carcinoma (ccRCC), and little data are currently available 
      on the treatment of non-clear cell renal cell carcinoma (nccRCC). nccRCC 
      encompasses a biologically heterogeneous group of kidney tumors that portend very 
      diverse prognoses and responses to therapy. This review is a pathway based 
      approach that highlights the current systemic treatment strategies for metastatic 
      nccRCC.
FAU - Sankin, Alexander
AU  - Sankin A
AD  - Memorial Sloan-Kettering Cancer Center , New York, NY , USA.
FAU - Hakimi, A Ari
AU  - Hakimi AA
AD  - Memorial Sloan-Kettering Cancer Center , New York, NY , USA.
FAU - Hsieh, James J
AU  - Hsieh JJ
AD  - Memorial Sloan-Kettering Cancer Center , New York, NY , USA.
FAU - Molina, Ana M
AU  - Molina AM
AD  - Weill Cornell Medical College , New York, NY , USA.
LA  - eng
GR  - T32 CA082088/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20150408
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC4389537
OTO - NOTNLM
OT  - metastatic
OT  - non-clear cell
OT  - renal cell carcinoma
OT  - targeted agents
OT  - treatment
EDAT- 2015/04/24 06:00
MHDA- 2015/04/24 06:01
PMCR- 2015/01/01
CRDT- 2015/04/24 06:00
PHST- 2015/01/02 00:00 [received]
PHST- 2015/03/05 00:00 [accepted]
PHST- 2015/04/24 06:00 [entrez]
PHST- 2015/04/24 06:00 [pubmed]
PHST- 2015/04/24 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2015.00067 [doi]
PST - epublish
SO  - Front Oncol. 2015 Apr 8;5:67. doi: 10.3389/fonc.2015.00067. eCollection 2015.