PMID- 25905454
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20150915
IS  - 1952-4013 (Electronic)
IS  - 1167-1122 (Linking)
VI  - 25
IP  - 4
DP  - 2015 Jul-Aug
TI  - Towards a specific marker for acute bradykinin-mediated angioedema attacks: a 
      literature review.
PG  - 290-5
LID - 10.1684/ejd.2015.2547 [doi]
AB  - BACKGROUND: Bradykinin-mediated angioedema (AE) is a rare disease characterised 
      by recurrent angioedema linked to acquired (e.g. angiotensin converting enzyme 
      inhibitor induced AE) or hereditary disorders (e.g. AE type I or II). As the 
      clinical picture can be misleading, diagnosis of this disease is sometimes 
      difficult. A bradykinin-mediated AE attack may be a therapeutic emergency which 
      requires access to effective, but expensive, treatments. Their prescription must 
      therefore be justified. No specific marker of acute bradykinin-mediated AE 
      attacks has yet been identified to facilitate the therapeutic decision but it has 
      been sought in many studies. PURPOSE: This article reviews the literature on this 
      type of biomarker, comparing candidate bradykinin-mediated AE markers to 
      candidate markers of mast cell activation. CONCLUSION: The most interesting 
      biomarkers are those linked to endothelial stress (VE cadherin, E-selectin, 
      endothelin-1, von Willebrand factor and its activity) which is significantly 
      increased during an AE attack. All these markers must now be validated by 
      prospective studies to determine their specificity and utility in diagnosis.
FAU - Deroux, Alban
AU  - Deroux A
AD  - Internal Medicine Department,, Centre national de reference des angioedemes 
      (CREAK).
FAU - Vilgrain, Isabelle
AU  - Vilgrain I
AD  - Universites des Alpes-Grenoble 1, 38041 Grenoble, France, CEA, DSV/iRTSV,, 
      INSERM, Unite 1036, Biologie du cancer et de l'infection, 17, rue des Martyrs, 
      38054 Grenoble, France.
FAU - Dumestre-Perard, Chantal
AU  - Dumestre-Perard C
AD  - Centre national de reference des angioedemes (CREAK),, Universites des 
      Alpes-Grenoble 1, 38041 Grenoble, France, Immunology Department, Grenoble 
      University Hospital, 38000 Grenoble, France.
FAU - Boccon-Gibod, Isabelle
AU  - Boccon-Gibod I
AD  - Internal Medicine Department,, Centre national de reference des angioedemes 
      (CREAK).
FAU - Bouillet, Laurence
AU  - Bouillet L
AD  - Internal Medicine Department,, Centre national de reference des angioedemes 
      (CREAK),, Universites des Alpes-Grenoble 1, 38041 Grenoble, France, CEA, 
      DSV/iRTSV,, INSERM, Unite 1036, Biologie du cancer et de l'infection, 17, rue des 
      Martyrs, 38054 Grenoble, France.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
RN  - 0 (Biomarkers)
RN  - 0 (Blood Coagulation Factors)
RN  - 0 (Complement C1 Inhibitor Protein)
RN  - 0 (E-Selectin)
RN  - 0 (Endothelin-1)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (Interleukins)
RN  - 0 (fibrin fragment D)
RN  - 820484N8I3 (Histamine)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Angioedema/blood/*diagnosis/urine
MH  - Biomarkers/blood/urine
MH  - Blood Coagulation Factors/*metabolism
MH  - Bradykinin/*metabolism
MH  - C-Reactive Protein/metabolism
MH  - Complement C1 Inhibitor Protein/*metabolism
MH  - E-Selectin/blood
MH  - Endothelin-1/blood
MH  - Fibrin Fibrinogen Degradation Products/metabolism
MH  - Histamine/blood/urine
MH  - Humans
MH  - Interleukins/blood
MH  - Mast Cells/metabolism
OTO - NOTNLM
OT  - C1 inhibitor
OT  - VE cadherin
OT  - biomarkers
OT  - endothelial dysfunction
OT  - hereditary angioedema
OT  - vascular permeability
EDAT- 2015/04/24 06:00
MHDA- 2016/06/23 06:00
CRDT- 2015/04/24 06:00
PHST- 2015/04/24 06:00 [entrez]
PHST- 2015/04/24 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
AID - ejd.2015.2547 [pii]
AID - 10.1684/ejd.2015.2547 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2015 Jul-Aug;25(4):290-5. doi: 10.1684/ejd.2015.2547.