PMID- 25906422 OWN - NLM STAT- MEDLINE DCOM- 20151228 LR - 20181113 IS - 1538-3008 (Electronic) IS - 0091-6331 (Print) IS - 0091-6331 (Linking) VI - 43 IP - 3 DP - 2015 Jul TI - Pathways Mediating Activity-Induced Enhancement of Recovery From Peripheral Nerve Injury. PG - 163-71 LID - 10.1249/JES.0000000000000047 [doi] AB - This article outlines the novel hypothesis that exercise promotes axon regeneration after peripheral nerve injury through neuronal brain-derived neurotrophic factor (BDNF), and there are three required means of promoting BDNF expression: 1) increased signaling through androgen receptors, 2) increased cAMP-responsive element-binding protein expression, and 3) increased expression of the transcription factor SRY-box containing gene 11. FAU - Sabatier, Manning J AU - Sabatier MJ AD - 1Departments of Rehabilitation Medicine and 2Cell Biology, Emory University School of Medicine, Atlanta, GA. FAU - English, Arthur W AU - English AW LA - eng GR - HD053669/HD/NICHD NIH HHS/United States GR - HD032571/HD/NICHD NIH HHS/United States GR - K12-GM00680-05/GM/NIGMS NIH HHS/United States GR - P01 HD032571/HD/NICHD NIH HHS/United States GR - R21 HD053669/HD/NICHD NIH HHS/United States GR - K12 GM000680/GM/NIGMS NIH HHS/United States GR - R01 NS057190/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Review PL - United States TA - Exerc Sport Sci Rev JT - Exercise and sport sciences reviews JID - 0375434 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cyclic AMP Response Element-Binding Protein) RN - 0 (Receptors, Androgen) RN - 0 (SOXC Transcription Factors) RN - 0 (Sox11 protein, mouse) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Animals MH - Axons/*physiology MH - Brain-Derived Neurotrophic Factor/physiology MH - Cyclic AMP Response Element-Binding Protein/metabolism MH - Humans MH - Nerve Regeneration/*physiology MH - Peripheral Nerve Injuries/*physiopathology MH - Receptors, Androgen/metabolism MH - SOXC Transcription Factors/metabolism MH - Signal Transduction PMC - PMC4470799 MID - NIHMS680651 EDAT- 2015/04/24 06:00 MHDA- 2015/12/29 06:00 PMCR- 2016/07/01 CRDT- 2015/04/24 06:00 PHST- 2015/04/24 06:00 [entrez] PHST- 2015/04/24 06:00 [pubmed] PHST- 2015/12/29 06:00 [medline] PHST- 2016/07/01 00:00 [pmc-release] AID - 10.1249/JES.0000000000000047 [doi] PST - ppublish SO - Exerc Sport Sci Rev. 2015 Jul;43(3):163-71. doi: 10.1249/JES.0000000000000047.