PMID- 25906800
OWN - NLM
STAT- MEDLINE
DCOM- 20160919
LR  - 20220310
IS  - 1526-3711 (Electronic)
IS  - 1526-3711 (Linking)
VI  - 16
IP  - 2
DP  - 2015 Feb 1
TI  - Serum and Saliva MMP-3 in Patients with OLP and Oral SCC.
PG  - 107-11
AB  - BACKGROUND: Matrix metalloproteinase-3 (MMP-3) plays a key role in development of 
      cancer. The purpose of this study was to assess MMP-3 in the serum and saliva of 
      patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). 
      MATERIALS AND METHODS: Thirty patients with OLP (8 reticular and 22 erosive 
      forms), and 20 patients with OSCC (6 in low stage and 14 in advanced stage), were 
      enrolled in this study, conducted at the Cancer Department, Clinic of Oral 
      Medicine, Tehran University of Medical Sciences. The serum and saliva MMP-3 was 
      assayed by ELISA method. Statistical analysis of the Student's t-test, ANOVA and 
      Pearson correlation coefficient was performed. The mean saliva and serum levels 
      of MMP-3 were significantly higher in patients with OSCC compared with OLP. 
      RESULTS: The serum and saliva MMP-3 concentrations increased from reticular form 
      of OLP to erosive form of OLP, and increased further to low stage of OSCC and 
      advanced stage of OSCC. Serum MMP-3 correlated significantly with unstimulated (r 
      = 0.310, p = 0.038) and stimulated (r = 0.365, p < 0.026) saliva MMP-3. 
      CONCLUSION: Serum and saliva MMP-3 levels appear associated with OLP and OSCC.
FAU - Agha-Hosseini, Farzaneh
AU  - Agha-Hosseini F
AD  - Department of Oral Medicine/Dental Research Center, School of Dentistry, Tehran 
      University of Medical Sciences, Tehran, Iran, Phone: +98-21-66402095, e-mail: 
      aghahose@sina.tums.ac.ir.
FAU - Mirzaii-Dizgah, Iraj
AU  - Mirzaii-Dizgah I
AD  - Department of Physiology, School of Medicine, AJA University of Medical Sciences, 
      Tehran, Iran.
FAU - Mahboobi, Nima
AU  - Mahboobi N
AD  - Department of Oral Medicine/Dental Research Center School of Dentistry, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Shirazian, Shiva
AU  - Shirazian S
AD  - Department of Oral Medicine/Dental Research Center School of Dentistry, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Harirchi, Iraj
AU  - Harirchi I
AD  - Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150201
PL  - India
TA  - J Contemp Dent Pract
JT  - The journal of contemporary dental practice
JID - 101090552
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/blood/*enzymology
MH  - Female
MH  - Gingival Diseases/blood/enzymology
MH  - Humans
MH  - Lichen Planus, Oral/blood/*enzymology
MH  - Lip Neoplasms/blood/enzymology
MH  - Male
MH  - Matrix Metalloproteinase 3/analysis/*blood
MH  - Middle Aged
MH  - Mouth Neoplasms/blood/*enzymology
MH  - Neoplasm Staging
MH  - Saliva/*enzymology
MH  - Tongue Diseases/blood/enzymology
MH  - Tongue Neoplasms/blood/enzymology
OTO - NOTNLM
OT  - MMP-3
OT  - Oral lichen planus
OT  - Squamous cell carcinoma
OT  - Saliva
EDAT- 2015/04/25 06:00
MHDA- 2016/09/20 06:00
CRDT- 2015/04/25 06:00
PHST- 2015/04/25 06:00 [entrez]
PHST- 2015/04/25 06:00 [pubmed]
PHST- 2016/09/20 06:00 [medline]
AID - 1526-3711-1399 [pii]
AID - 10.5005/jp-journals-10024-1645 [doi]
PST - epublish
SO  - J Contemp Dent Pract. 2015 Feb 1;16(2):107-11. doi: 
      10.5005/jp-journals-10024-1645.