PMID- 25907206
OWN - NLM
STAT- MEDLINE
DCOM- 20151203
LR  - 20220317
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 29
IP  - 5
DP  - 2015 May
TI  - The diagnostic accuracy of spectral-domain optical coherence tomography for 
      neovascular age-related macular degeneration: a comparison with fundus 
      fluorescein angiography.
PG  - 602-9; quiz 610
LID - 10.1038/eye.2015.44 [doi]
AB  - PURPOSE: To evaluate the diagnostic accuracy of spectral-domain optical coherence 
      tomography (SD-OCT) for neovascular age-related macular degeneration (nAMD): a 
      comparison against fundus fluorescein angiography (FFA). METHODS: A retrospective 
      review of SD-OCT, colour fundus photographs (FP), and FFA of 411 consecutive 
      patients referred to a rapid access Macular Clinic over a 4-year period was 
      performed. FFA images were reviewed non-stereoscopically. SD-OCT images were 
      acquired using the Topcon 3D OCT-1000 instrument. All FFA and OCT images were 
      graded by at least two ophthalmologists independently. Side-by-side grading took 
      place with immediate open discussion and adjudication. If there was disagreement 
      between the two grading ophthalmologists or they were not 90% confident of their 
      assigned grade, then adjudication by a third ophthalmologist was performed. 
      RESULTS: A total of 278 eyes were graded as having choroidal neovascularisation 
      (CNV) with SD-OCT and 231 diagnosed with FFA. The main diagnostic CNV 
      classifications on FFA were: classic no occult in 27 eyes, predominantly classic 
      in 16, minimally classic in 50, occult in 129, and 9 peripapillary membranes. 
      There were a total of 47 false positives with SD-OCT: a rate of 16.9%. The 
      sensitivity and specificity of SD-OCT alone for detecting CNV was 100 and 80.8%, 
      respectively. CONCLUSION: Our study confirms SD-OCT in comparison to the 
      reference standard of non-stereoscopic FFA is highly sensitive at detecting newly 
      presenting nAMD in the setting of a specialist AMD clinic where the 
      investigations are interpreted by trained specialists. However, it does not seem 
      accurate enough to replace FFA in the diagnosis on nAMD in current practice.
FAU - Wilde, C
AU  - Wilde C
AD  - Ophthalmology and Vision Sciences, Division of Clinical Neurosciences, B Floor, 
      EENT Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
FAU - Patel, M
AU  - Patel M
AD  - Ophthalmology, Derby Hospitals NHS Foundation Trust, Derby, UK.
FAU - Lakshmanan, A
AU  - Lakshmanan A
AD  - Eye Clinic, Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, 
      UK.
FAU - Amankwah, R
AU  - Amankwah R
AD  - Eye Clinic, Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, 
      UK.
FAU - Dhar-Munshi, S
AU  - Dhar-Munshi S
AD  - Eye Clinic, Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, 
      UK.
FAU - Amoaku, W
AU  - Amoaku W
AD  - Ophthalmology and Vision Sciences, Division of Clinical Neurosciences, B Floor, 
      EENT Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
CN  - Medscape
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150424
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroidal Neovascularization/*diagnosis
MH  - False Positive Reactions
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
MH  - Wet Macular Degeneration/*diagnosis
PMC - PMC4429282
EDAT- 2015/04/25 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/05/01
CRDT- 2015/04/25 06:00
PHST- 2014/11/01 00:00 [received]
PHST- 2015/01/28 00:00 [accepted]
PHST- 2015/04/25 06:00 [entrez]
PHST- 2015/04/25 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - eye201544 [pii]
AID - 10.1038/eye.2015.44 [doi]
PST - ppublish
SO  - Eye (Lond). 2015 May;29(5):602-9; quiz 610. doi: 10.1038/eye.2015.44. Epub 2015 
      Apr 24.