PMID- 25908174
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20211124
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 36
IP  - 10
DP  - 2015 Sep
TI  - A novel long noncoding RNA LINC01133 is upregulated in lung squamous cell cancer 
      and predicts survival.
PG  - 7465-71
LID - 10.1007/s13277-015-3460-9 [doi]
AB  - Lung adenocarcinoma (LAD) and lung squamous cell cancer (LSCC) are two major 
      histological types of non-small cell lung cancer. LSCC differs greatly from LAD 
      in many aspects. Accumulating evidence has shown that long noncoding RNA (lncRNA) 
      plays an important role in the process of carcinogenesis and tumor progression. 
      Expression of lncRNA is highly tissue-specific and could be biomarkers for cancer 
      diagnosis and prognosis. Here, we identified differentially expressed lncRNA 
      between LSCC and LAD by data mining of Affymetrix HG-U133 Plus 2.0 microarray. A 
      set of 1646 differentially expressed lncRNA transcripts were identified. Among 
      these lncRNAs, a novel lncRNA, LINC01133, showed the largest fold change among 
      large intergenic noncoding RNAs. Quantitative real-time polymerase chain reaction 
      (PCR) assay confirmed that LINC01133 was upregulated in LSCC (increasing fold 
      6.4, P < 0.01) but not in the LAD samples. LSCC patients with higher expression 
      level of LINC01133 had shorter survival time (hazard ratio = 2.383; 95 % 
      confidence interval 1.023-5.547, P = 0.044). Wound-healing and transwell assays 
      demonstrated that silence of LINC01133 by small interfering RNA (siRNA) inhibited 
      invasion ability of LSCC cell line. Thus, a set of lncRNA was differentially 
      expressed between LAD and LSCC and could serve as potential biomarkers.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Department of Respiratory Disease, Huashan Hospital, Fudan University, No. 12 
      Wulumuqi Middle Road, Shanghai, 200040, China.
FAU - Zhu, Ning
AU  - Zhu N
AD  - Department of Respiratory Disease, Huashan Hospital, Fudan University, No. 12 
      Wulumuqi Middle Road, Shanghai, 200040, China.
FAU - Chen, Xiaodong
AU  - Chen X
AD  - Department of Respiratory Disease, Huashan Hospital, Fudan University, No. 12 
      Wulumuqi Middle Road, Shanghai, 200040, China. chen_xd8@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20150424
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Messenger)
RN  - 0 (long non-coding RNA LINC01133, human)
SB  - IM
MH  - Adenocarcinoma/genetics/mortality
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/*mortality
MH  - Carcinoma, Squamous Cell/*genetics/*mortality
MH  - Computational Biology/*methods
MH  - Follow-Up Studies
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/genetics/mortality
MH  - Oligonucleotide Array Sequence Analysis
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
MH  - RNA, Messenger/genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Survival Rate
OTO - NOTNLM
OT  - LINC01133
OT  - Lung squamous cell cancer
OT  - Microarray
OT  - lncRNA
EDAT- 2015/04/25 06:00
MHDA- 2016/02/03 06:00
CRDT- 2015/04/25 06:00
PHST- 2015/03/15 00:00 [received]
PHST- 2015/04/13 00:00 [accepted]
PHST- 2015/04/25 06:00 [entrez]
PHST- 2015/04/25 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
AID - 10.1007/s13277-015-3460-9 [pii]
AID - 10.1007/s13277-015-3460-9 [doi]
PST - ppublish
SO  - Tumour Biol. 2015 Sep;36(10):7465-71. doi: 10.1007/s13277-015-3460-9. Epub 2015 
      Apr 24.