PMID- 25908537
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20220129
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 6
DP  - 2015 Apr 24
TI  - A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 
      induction by dendritic cells.
PG  - 6920
LID - 10.1038/ncomms7920 [doi]
LID - 6920
AB  - Dendritic cells (DCs) direct CD4(+) T-cell differentiation into diverse helper 
      (Th) subsets that are required for protection against varied infections. However, 
      the mechanisms used by DCs to promote Th2 responses, which are important both for 
      immunity to helminth infection and in allergic disease, are currently poorly 
      understood. We demonstrate a key role for the protein methyl-CpG-binding domain-2 
      (Mbd2), which links DNA methylation to repressive chromatin structure, in 
      regulating expression of a range of genes that are associated with optimal DC 
      activation and function. In the absence of Mbd2, DCs display reduced phenotypic 
      activation and a markedly impaired capacity to initiate Th2 immunity against 
      helminths or allergens. These data identify an epigenetic mechanism that is 
      central to the activation of CD4(+) T-cell responses by DCs, particularly in Th2 
      settings, and reveal methyl-CpG-binding proteins and the genes under their 
      control as possible therapeutic targets for type-2 inflammation.
FAU - Cook, Peter C
AU  - Cook PC
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester M3 9NT, UK.
FAU - Owen, Heather
AU  - Owen H
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Deaton, Aimee M
AU  - Deaton AM
AD  - Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 
      3BF, UK.
FAU - Borger, Jessica G
AU  - Borger JG
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Brown, Sheila L
AU  - Brown SL
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester M3 9NT, UK.
FAU - Clouaire, Thomas
AU  - Clouaire T
AD  - Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 
      3BF, UK.
FAU - Jones, Gareth-Rhys
AU  - Jones GR
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester M3 9NT, UK.
FAU - Jones, Lucy H
AU  - Jones LH
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Lundie, Rachel J
AU  - Lundie RJ
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Marley, Angela K
AU  - Marley AK
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Morrison, Vicky L
AU  - Morrison VL
AD  - Medical Research Institute, Ninewells Hospital and Medical School, University of 
      Dundee, Dundee, DD1 9SY UK.
FAU - Phythian-Adams, Alexander T
AU  - Phythian-Adams AT
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester M3 9NT, UK.
FAU - Wachter, Elisabeth
AU  - Wachter E
AD  - Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 
      3BF, UK.
FAU - Webb, Lauren M
AU  - Webb LM
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester M3 9NT, UK.
FAU - Sutherland, Tara E
AU  - Sutherland TE
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Thomas, Graham D
AU  - Thomas GD
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Grainger, John R
AU  - Grainger JR
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester M3 9NT, UK.
FAU - Selfridge, Jim
AU  - Selfridge J
AD  - Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 
      3BF, UK.
FAU - McKenzie, Andrew N J
AU  - McKenzie AN
AD  - Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH UK.
FAU - Allen, Judith E
AU  - Allen JE
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Fagerholm, Susanna C
AU  - Fagerholm SC
AD  - Medical Research Institute, Ninewells Hospital and Medical School, University of 
      Dundee, Dundee, DD1 9SY UK.
FAU - Maizels, Rick M
AU  - Maizels RM
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Ivens, Alasdair C
AU  - Ivens AC
AD  - Institute of Immunology and Infection Research, Centre for Immunity, Infection 
      and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh 
      EH9 3FL, UK.
FAU - Bird, Adrian
AU  - Bird A
AD  - Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 
      3BF, UK.
FAU - MacDonald, Andrew S
AU  - MacDonald AS
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, Manchester M3 9NT, UK.
LA  - eng
GR  - BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - N01AI30026/AI/NIAID NIH HHS/United States
GR  - MC_U105178805/MRC_/Medical Research Council/United Kingdom
GR  - G120/822/MRC_/Medical Research Council/United Kingdom
GR  - G0701437/MRC_/Medical Research Council/United Kingdom
GR  - 106122/WT_/Wellcome Trust/United Kingdom
GR  - MR/K01207X/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150424
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (Allergens)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Mbd2 protein, mouse)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cell Polarity
MH  - Chromatin Immunoprecipitation
MH  - DNA Methylation
MH  - DNA-Binding Proteins/genetics/*immunology
MH  - Dendritic Cells/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Epigenesis, Genetic
MH  - Flow Cytometry
MH  - Gene Expression Regulation/*genetics
MH  - Hypersensitivity/immunology
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Pyroglyphidae/immunology
MH  - RNA, Messenger/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Schistosoma mansoni/immunology
MH  - Schistosomiasis mansoni/immunology
MH  - Th2 Cells/*immunology
PMC - PMC4413429
MID - EMS62642
OID - NLM: EMS62642
EDAT- 2015/04/25 06:00
MHDA- 2016/04/06 06:00
PMCR- 2015/05/07
CRDT- 2015/04/25 06:00
PHST- 2015/01/22 00:00 [received]
PHST- 2015/03/13 00:00 [accepted]
PHST- 2015/04/25 06:00 [entrez]
PHST- 2015/04/25 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
PHST- 2015/05/07 00:00 [pmc-release]
AID - ncomms7920 [pii]
AID - 10.1038/ncomms7920 [doi]
PST - epublish
SO  - Nat Commun. 2015 Apr 24;6:6920. doi: 10.1038/ncomms7920.