PMID- 25909513
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20200306
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 4
DP  - 2015
TI  - Effects of Clozapine and other Atypical Antipsychotics on Infants Development Who 
      Were Exposed to as Fetus: A Post-Hoc Analysis.
PG  - e0123373
LID - 10.1371/journal.pone.0123373 [doi]
LID - e0123373
AB  - OBJECTIVE: To investigate the developmental effects of clozapine and other 
      atypical antipsychotics on infants who were exposed to as fetus. METHOD: The 
      developmental progress of 33 infants who were exposed to clozapine as fetus was 
      compared to 30 infants who were exposed to risperidone, olanzapine or quetiapine 
      as fetus by assessing Apgar scoring, birth weight at birth, body weight, height, 
      and the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) 
      at months 2, 6 and 12 of age. Five subscale scores of BSID-III including 
      cognitive, language, motor, social-emotional, and adaptive behavior were also 
      compared. Student's t test and Chi-square analysis were used as appropriate. 
      Repeated measurements were evaluated by analysis of covariance. RESULTS: Of the 
      63 infants, 58 (92.1%) completed a 12-month study period. At the age of 2 and 6 
      months, mean adaptive behavior scores of BSID-III were significantly lower in 
      clozapine-exposed infants than infants who exposed to other atypical 
      antipsychotic at 2 and 6 months of age. More clozapine-exposed infants had 
      delayed development (defined as the subscale score of <85) for adaptive behavior 
      at 2 and 6 months of age. There was no difference between the two groups for 
      cognitive, language, motor, social and emotional at 2, 6 and 12 months of age. 
      More infants who were exposed to clozapine as fetus (25 of 33, 75.8%) had 
      disturbed sleep and a labile state than those who were exposed to other atypical 
      antipsychotics (8 of 30, 26.7%) during 2 months of age (P<0.001). CONCLUSION: 
      These results suggest that clozapine has more adaptive behavior effects on 
      infants who were exposed to as a fetus than other atypical antipsychotics at 2 
      and 6 months of age. TRIAL REGISTRATION: ClinicalTrials.gov NCT01479400.
FAU - Shao, Ping
AU  - Shao P
AD  - Institute of Mental Health of The Second Xiangya Hospital, Central South 
      University, 139# Renmin Middle Road, Changsha 410011, Hunan, P.R. China; Brains 
      Hospital of Hunan Province, 427# Renmin Middle Road (3 Duan), Changsha 410007, 
      Hunan, P.R. China.
FAU - Ou, Jianjun
AU  - Ou J
AD  - Institute of Mental Health of The Second Xiangya Hospital, Central South 
      University, 139# Renmin Middle Road, Changsha 410011, Hunan, P.R. China.
FAU - Peng, Mei
AU  - Peng M
AD  - Department of Obstetrical of The Second Xiangya Hospital, Central South 
      University, 139# Renmin Middle Road,Changsha 410011, Hunan, P.R. China.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - Institute of Mental Health of The Second Xiangya Hospital, Central South 
      University, 139# Renmin Middle Road, Changsha 410011, Hunan, P.R. China.
FAU - Chen, Jindong
AU  - Chen J
AD  - Institute of Mental Health of The Second Xiangya Hospital, Central South 
      University, 139# Renmin Middle Road, Changsha 410011, Hunan, P.R. China.
FAU - Wu, Renrong
AU  - Wu R
AD  - Institute of Mental Health of The Second Xiangya Hospital, Central South 
      University, 139# Renmin Middle Road, Changsha 410011, Hunan, P.R. China.
LA  - eng
SI  - ClinicalTrials.gov/NCT01479400
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150424
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antipsychotic Agents)
RN  - J60AR2IKIC (Clozapine)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*adverse effects
MH  - Body Height
MH  - Body Weight
MH  - Child Development/*drug effects
MH  - Clozapine/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Maternal Exposure/*adverse effects
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - *Prenatal Exposure Delayed Effects
MH  - Risk Factors
PMC - PMC4409220
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/04/25 06:00
MHDA- 2016/01/20 06:00
PMCR- 2015/04/24
CRDT- 2015/04/25 06:00
PHST- 2014/08/02 00:00 [received]
PHST- 2015/02/23 00:00 [accepted]
PHST- 2015/04/25 06:00 [entrez]
PHST- 2015/04/25 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
PHST- 2015/04/24 00:00 [pmc-release]
AID - PONE-D-14-25925 [pii]
AID - 10.1371/journal.pone.0123373 [doi]
PST - epublish
SO  - PLoS One. 2015 Apr 24;10(4):e0123373. doi: 10.1371/journal.pone.0123373. 
      eCollection 2015.