PMID- 25909793
OWN - NLM
STAT- MEDLINE
DCOM- 20150707
LR  - 20181023
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 115
IP  - 1
DP  - 2015
TI  - [No effect of the BDNF Val66Met polymorphism on cognitive deficit in patients 
      with schizophrenia and on the risk of the disease in their relatives].
PG  - 75-79
LID - 10.17116/jnevro20151151175-79 [doi]
AB  - OBJECTIVE: The brain-derived neurotrophic factor (BDNF) gene is thought to be a 
      candidate gene for schizophrenia. At the same time, many studies failed to find 
      the association between BDNF and the disease though the contribution of the BDNF 
      Val66Met polymorphism to the variance of characteristics of schizophrenia has 
      been confirmed. Authors suggested that this contribution was the consequence of 
      the involvement of this gene in the formation of "cognitive reserve" that had a 
      protective effect on the different aspects of the disease. This protective effect 
      should emerge in relatively intact cognitive function in patients with the 
      protective Val66Met genotype as well as in the accumulation of the protective 
      genotypes in unaffected relatives. MATERIAL AND METHODS: We examined 169 patients 
      with schizophrenia spectrum disorders, 320 their first-degree relatives and 
      control groups using molecular-genetic and experimental psychological methods. 
      RESULTS: No effect of the Val66Met polymorphism on verbal memory, executive 
      functions and total index of cognitive functioning was found. Besides, we did not 
      find any differences in Val66Met genotype frequencies in first-degree relatives 
      of patients with schizophrenia and healthy people without family history of 
      schizophrenia. CONCLUSION: The results do not support our hypothesis that BDNF is 
      a gene of "cognitive reserve".
FAU - Alfimova, M V
AU  - Alfimova MV
AD  - Mental Health Research Center, Russian Academy of Medical Sciences, Moscow.
FAU - Golimbet, V E
AU  - Golimbet VE
AD  - Mental Health Research Center, Russian Academy of Medical Sciences, Moscow.
FAU - Korovaitseva, G I
AU  - Korovaitseva GI
AD  - Mental Health Research Center, Russian Academy of Medical Sciences, Moscow.
FAU - Lezheiko, T V
AU  - Lezheiko TV
AD  - Mental Health Research Center, Russian Academy of Medical Sciences, Moscow.
FAU - Gabaeva, M V
AU  - Gabaeva MV
AD  - Mental Health Research Center, Russian Academy of Medical Sciences, Moscow.
FAU - Oleichik, I V
AU  - Oleichik IV
AD  - Mental Health Research Center, Russian Academy of Medical Sciences, Moscow.
FAU - Stolyarov, S A
AU  - Stolyarov SA
AD  - Mental Health Research Center, Russian Academy of Medical Sciences, Moscow.
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition Disorders/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Pedigree
MH  - Polymorphism, Genetic
MH  - Schizophrenia/*genetics
MH  - Valine/genetics
MH  - Young Adult
EDAT- 2015/04/25 06:00
MHDA- 2015/07/08 06:00
CRDT- 2015/04/25 06:00
PHST- 2015/04/25 06:00 [entrez]
PHST- 2015/04/25 06:00 [pubmed]
PHST- 2015/07/08 06:00 [medline]
AID - 10.17116/jnevro20151151175-79 [doi]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(1):75-79. doi: 
      10.17116/jnevro20151151175-79.