PMID- 25910175
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20151001
IS  - 1678-2690 (Electronic)
IS  - 0001-3765 (Linking)
VI  - 87
IP  - 3
DP  - 2015 Sep
TI  - Neurotrophins, cytokines, oxidative parameters and funcionality in Progressive 
      Muscular Dystrophies.
PG  - 1809-18
LID - S0001-37652015005040508 [pii]
LID - 10.1590/0001-3765201520140508 [doi]
AB  - We investigated the levels of brain derived-neurotrophic factor (BDNF), cytokines 
      and oxidative parameters in serum and tried to correlate them with the age and 
      functionality of patients with Progressive Muscle Dystrophies (PMD). The patients 
      were separated into six groups (case and controls pared by age and gender), as 
      follows: Duchenne Muscular Dystrophy (DMD); Steinert Myotonic Dystrophy (SMD); 
      and Limb-girdle Muscular Dystrophy type-2A (LGMD2A). DMD patients (+/- 17.9 years 
      old) had a decrease of functionality, an increase in the IL-1beta and TNF-alpha levels 
      and a decrease of IL-10 levels and superoxide dismutase activity in serum. SMD 
      patients (+/- 25.8 years old) had a decrease of BDNF and IL-10 levels and 
      superoxide dismutase activity and an increase of IL-1beta levels in serum. LGMD2A 
      patients (+/- 27.7 years old) had an decrease only in serum levels of IL-10. This 
      research showed the first evidence of BDNF involvement in the SMD patients and a 
      possible unbalance between pro-inflammatory and anti-inflammatory cytokine 
      levels, along with decreased superoxide dismutase activity in serum of DMD and 
      SMD patients.
FAU - Comim, Clarissa M
AU  - Comim CM
AD  - Universidade do Sul de Santa Catarina, Palhoca, SC, BR.
FAU - Mathia, Gisiane B
AU  - Mathia GB
AD  - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR.
FAU - Hoepers, Andreza
AU  - Hoepers A
AD  - Universidade do Sul de Santa Catarina, Palhoca, SC, BR.
FAU - Tuon, Lisiane
AU  - Tuon L
AD  - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR.
FAU - Kapczinski, Flavio
AU  - Kapczinski F
AD  - Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, BR.
FAU - Dal-Pizzol, Felipe
AU  - Dal-Pizzol F
AD  - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR.
FAU - Quevedo, Joao
AU  - Quevedo J
AD  - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR.
FAU - Rosa, Maria I
AU  - Rosa MI
AD  - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150417
PL  - Brazil
TA  - An Acad Bras Cienc
JT  - Anais da Academia Brasileira de Ciencias
JID - 7503280
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Disability Evaluation
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscular Dystrophies, Limb-Girdle/*blood
MH  - Muscular Dystrophy, Duchenne/*blood
MH  - Myotonic Dystrophy/*blood
MH  - Nerve Growth Factors/*blood
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2015/04/25 06:00
MHDA- 2016/04/06 06:00
CRDT- 2015/04/25 06:00
PHST- 2015/04/25 06:00 [entrez]
PHST- 2015/04/25 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
AID - S0001-37652015005040508 [pii]
AID - 10.1590/0001-3765201520140508 [doi]
PST - ppublish
SO  - An Acad Bras Cienc. 2015 Sep;87(3):1809-18. doi: 10.1590/0001-3765201520140508. 
      Epub 2015 Apr 17.