PMID- 25910281
OWN - NLM
STAT- MEDLINE
DCOM- 20160713
LR  - 20210430
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 123
IP  - 10
DP  - 2015 Oct
TI  - Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity 
      and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort 
      (Crete, Greece).
PG  - 1015-21
LID - 10.1289/ehp.1409062 [doi]
AB  - BACKGROUND: Prenatal exposure to endocrine-disrupting chemicals such as 
      persistent organic pollutants (POPs) may increase risk of obesity later in life. 
      OBJECTIVE: We examined the relation of in utero POPs exposure to offspring 
      obesity and cardiometabolic risk factors at 4 years of age in the Rhea 
      mother-child cohort in Crete, Greece (n = 689). METHODS: We determined 
      concentrations of polychlorinated biphenyls (PCBs), 
      dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) in 
      first-trimester maternal serum. We measured child weight, height, waist 
      circumference, skinfold thicknesses, blood pressure (BP), blood levels of lipids, 
      C-reactive protein, and adipokines at 4 years of age. Childhood obesity was 
      defined using age- and sex-specific cut points for body mass index (BMI) as 
      recommended by the International Obesity Task Force. RESULTS: On multivariable 
      regression analyses, a 10-fold increase in HCB was associated with a higher BMI 
      z-score (adjusted beta = 0.49; 95% CI: 0.12, 0.86), obesity [relative risk (RR) = 
      8.14; 95% CI: 1.85, 35.81], abdominal obesity (RR = 3.49; 95% CI: 1.08, 11.28), 
      greater sum of skinfold thickness (beta = 7.71 mm; 95% CI: 2.04, 13.39), and higher 
      systolic BP (beta = 4.34 mmHg; 95% CI: 0.63, 8.05) at 4 years of age. Prenatal DDE 
      exposure was associated with higher BMI z-score (beta = 0.27; 95% CI: 0.04, 0.5), 
      abdominal obesity (RR = 3.76; 95% CI: 1.70, 8.30), and higher diastolic BP (beta = 
      1.79 mmHg; 95% CI: 0.13, 3.46). PCBs were not significantly associated with 
      offspring obesity or cardiometabolic risk factors. CONCLUSIONS: Prenatal exposure 
      to DDE and HCB was associated with excess adiposity and higher blood pressure 
      levels in early childhood.
FAU - Vafeiadi, Marina
AU  - Vafeiadi M
AD  - Department of Social Medicine, Faculty of Medicine, University of Crete, 
      Heraklion, Greece.
FAU - Georgiou, Vaggelis
AU  - Georgiou V
FAU - Chalkiadaki, Georgia
AU  - Chalkiadaki G
FAU - Rantakokko, Panu
AU  - Rantakokko P
FAU - Kiviranta, Hannu
AU  - Kiviranta H
FAU - Karachaliou, Marianna
AU  - Karachaliou M
FAU - Fthenou, Eleni
AU  - Fthenou E
FAU - Venihaki, Maria
AU  - Venihaki M
FAU - Sarri, Katerina
AU  - Sarri K
FAU - Vassilaki, Maria
AU  - Vassilaki M
FAU - Kyrtopoulos, Soterios A
AU  - Kyrtopoulos SA
FAU - Oken, Emily
AU  - Oken E
FAU - Kogevinas, Manolis
AU  - Kogevinas M
FAU - Chatzi, Leda
AU  - Chatzi L
LA  - eng
GR  - K24 HD069408/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150424
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
CIN - Environ Health Perspect. 2015 Oct;123(10):A265. PMID: 26421652
MH  - Adolescent
MH  - Adult
MH  - *Anthropometry
MH  - Blood Chemical Analysis
MH  - *Blood Pressure
MH  - Child, Preschool
MH  - Dichlorodiphenyl Dichloroethylene/toxicity
MH  - Endocrine Disruptors/toxicity
MH  - *Environmental Exposure
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Greece/epidemiology
MH  - Hexachlorobenzene/toxicity
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Pediatric Obesity/chemically induced/*epidemiology
MH  - Polychlorinated Biphenyls/toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*epidemiology
MH  - Risk Factors
MH  - Young Adult
PMC - PMC4590761
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2015/04/25 06:00
MHDA- 2016/07/14 06:00
PMCR- 2015/10/01
CRDT- 2015/04/25 06:00
PHST- 2014/08/11 00:00 [received]
PHST- 2015/04/21 00:00 [accepted]
PHST- 2015/04/25 06:00 [entrez]
PHST- 2015/04/25 06:00 [pubmed]
PHST- 2016/07/14 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - ehp.1409062 [pii]
AID - 10.1289/ehp.1409062 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2015 Oct;123(10):1015-21. doi: 10.1289/ehp.1409062. Epub 
      2015 Apr 24.