PMID- 25910577
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20181202
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 77
DP  - 2016 Jan
TI  - Are age and sex differences in brain oxytocin receptors related to maternal and 
      infanticidal behavior in naive mice?
PG  - 132-40
LID - S0018-506X(15)00056-2 [pii]
LID - 10.1016/j.yhbeh.2015.04.006 [doi]
AB  - This article is part of a Special Issue "Parental Care". There is significant 
      variability in the behavioral responses displayed by naive young and adult mice 
      when first exposed to pups. This variability has been associated with differences 
      in the expression of oxytocin receptors (OXTRs) in the brain in several species. 
      Experiment I investigated the behavioral responses of juvenile, adolescent, and 
      adult CB57BL/6 males and females when first exposed to pups. We found an age 
      increase in maternal females (11% of juveniles, 20% of adolescents, and 50% of 
      young adults), and infanticidal males (0% of juveniles, 30% of adolescents, 44.5% 
      of young adults, and 100% of older adults). Experiment II investigated OXTR 
      density in the brain of juvenile and adult mice. Our results revealed an age 
      decline in the density of OXTR in several brain regions, including the lateral 
      septum, cingulated and posterior paraventricular thalamic nucleus in both males 
      and females. Adult females had higher OXTR density in the ventromedial 
      nucleus/postero-ventral hypothalamus (VMH) and the accessory olfactory bulb 
      (AOB), but lower density in the ventral region of the lateral septum (LSv) than 
      juveniles. Males had lower OXTR density in the anterior olfactory area (AOA) 
      compared to juveniles. No age or sex differences were found in the medial 
      preoptic area, and amygdaloid nuclei, among other brain regions. This study 
      suggests that 1) maturation of parental and infanticidal behavioral responses is 
      not reached until adulthood; 2) the pattern of development of OXTR in the mouse 
      brain is unique, region specific, and differs from that observed in other 
      rodents; 3) either up or down regulation of OXTR in a few brain regions 
      (VMH/AOB/LSv/AOA) might contribute to age or sex differences in parental or 
      infanticidal behavior.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Olazabal, Daniel E
AU  - Olazabal DE
AD  - Departamento de Fisiologia, Facultad de Medicina, UdelaR, Montevideo, Uruguay. 
      Electronic address: dolazabal@fmed.edu.uy.
FAU - Alsina-Llanes, Marcela
AU  - Alsina-Llanes M
AD  - Departamento de Fisiologia, Facultad de Medicina, UdelaR, Montevideo, Uruguay.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150422
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Receptors, Oxytocin)
SB  - IM
MH  - Age Factors
MH  - Amygdala/metabolism
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Brain/*metabolism
MH  - Female
MH  - Male
MH  - Maternal Behavior/*physiology
MH  - Mice
MH  - Receptors, Oxytocin/*metabolism
MH  - *Sex Characteristics
MH  - Sex Factors
OTO - NOTNLM
OT  - Development
OT  - Hypothalamus
OT  - Infanticidal behavior
OT  - Mouse
OT  - Olfaction
OT  - Oxytocin receptor
OT  - Parental behavior
EDAT- 2015/04/26 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/04/26 06:00
PHST- 2015/02/09 00:00 [received]
PHST- 2015/04/04 00:00 [revised]
PHST- 2015/04/15 00:00 [accepted]
PHST- 2015/04/26 06:00 [entrez]
PHST- 2015/04/26 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - S0018-506X(15)00056-2 [pii]
AID - 10.1016/j.yhbeh.2015.04.006 [doi]
PST - ppublish
SO  - Horm Behav. 2016 Jan;77:132-40. doi: 10.1016/j.yhbeh.2015.04.006. Epub 2015 Apr 
      22.