PMID- 25910953
OWN - NLM
STAT- MEDLINE
DCOM- 20151217
LR  - 20150825
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 62
IP  - 3
DP  - 2015 Sep
TI  - Venous claudication in Behcet's disease.
PG  - 698-703.e1
LID - S0741-5214(15)00857-5 [pii]
LID - 10.1016/j.jvs.2015.02.060 [doi]
AB  - OBJECTIVE: We have previously shown that venous claudication is significantly 
      more common among patients with Behcet's disease (BD) and had proposed that this 
      was a "venous claudication" because it was specifically more common among men 
      with lower extremity venous thrombosis (LEVT). With this study, we reassessed the 
      presence of claudication prospectively by a questionnaire and a treadmill 
      exercise. METHODS: We studied all men: 61 BD patients with LEVT, 40 BD patients 
      without vascular involvement, and 56 healthy controls. Venous claudication was 
      assessed by a standardized questionnaire. In addition, patients were asked to 
      walk on a treadmill for 10 minutes. Patients who experienced symptoms consistent 
      with venous claudication but still able to walk and those who had to give up the 
      treadmill exercise were noted. Ankle-brachial pressure indices measured before 
      and after the treadmill test did not indicate any peripheral arterial disease. 
      RESULTS: Twenty-one BD patients with LEVT (34%), two BD patients without vascular 
      involvement (5%), and none of the healthy controls described venous claudication 
      when assessed with the questionnaire (P < .001). There were significantly more 
      patients who described claudication during the treadmill exercise among patients 
      with LEVT (21%) compared with those with no vascular disease (8%) and healthy 
      controls (2%) (P = .002). Finally, only those with LEVT (6 of 61) had to stop the 
      treadmill challenge because of claudication. CONCLUSIONS: Venous claudication is 
      a severe and frequent symptom, being present in up to one third of BD patients 
      with LEVT. It impairs walking capacity in 10% of these patients.
CI  - Copyright (c) 2015 Society for Vascular Surgery. Published by Elsevier Inc. All 
      rights reserved.
FAU - Ugurlu, Serdal
AU  - Ugurlu S
AD  - Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, 
      University of Istanbul, Istanbul, Turkey.
FAU - Seyahi, Emire
AU  - Seyahi E
AD  - Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, 
      University of Istanbul, Istanbul, Turkey. Electronic address: eseyahi@yahoo.com.
FAU - Oktay, Veysel
AU  - Oktay V
AD  - Department of Cardiology, Institute of Cardiology, University of Istanbul, 
      Istanbul, Turkey.
FAU - Kantarci, Fatih
AU  - Kantarci F
AD  - Department of Radiology, Cerrahpasa Medical Faculty, University of Istanbul, 
      Istanbul, Turkey.
FAU - Tuzun, Hasan
AU  - Tuzun H
AD  - Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, University of 
      Istanbul, Istanbul, Turkey.
FAU - Yigit, Zerrin
AU  - Yigit Z
AD  - Department of Cardiology, Institute of Cardiology, University of Istanbul, 
      Istanbul, Turkey.
FAU - Arslan, Caner
AU  - Arslan C
AD  - Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, University of 
      Istanbul, Istanbul, Turkey.
FAU - Yazici, Hasan
AU  - Yazici H
AD  - Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, 
      University of Istanbul, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20150421
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Adult
MH  - Ankle Brachial Index
MH  - Behcet Syndrome/*complications/diagnosis/physiopathology
MH  - Case-Control Studies
MH  - Exercise Test
MH  - Exercise Tolerance
MH  - Humans
MH  - Intermittent Claudication/diagnosis/*etiology/physiopathology
MH  - Lower Extremity/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Veins/physiopathology
MH  - Walking
MH  - Young Adult
EDAT- 2015/04/26 06:00
MHDA- 2015/12/19 06:00
CRDT- 2015/04/26 06:00
PHST- 2014/12/09 00:00 [received]
PHST- 2015/02/11 00:00 [accepted]
PHST- 2015/04/26 06:00 [entrez]
PHST- 2015/04/26 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
AID - S0741-5214(15)00857-5 [pii]
AID - 10.1016/j.jvs.2015.02.060 [doi]
PST - ppublish
SO  - J Vasc Surg. 2015 Sep;62(3):698-703.e1. doi: 10.1016/j.jvs.2015.02.060. Epub 2015 
      Apr 21.