PMID- 25912229
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20220409
IS  - 1600-0463 (Electronic)
IS  - 0903-4641 (Linking)
VI  - 123
IP  - 7
DP  - 2015 Jul
TI  - Profiling peripheral microRNAs in obesity and type 2 diabetes mellitus.
PG  - 580-5
LID - 10.1111/apm.12389 [doi]
AB  - Mechanisms of type 2 diabetes mellitus (T2DM) remain elusive, in which obesity 
      (OB) is considered as one of the major risk factors for the disease. A microRNA 
      (miRNA) is a small non-coding RNA molecule functioning in RNA silencing and 
      post-transcriptional regulation of gene expression. It has been demonstrated that 
      some miRNAs can exist in serum stably and is closely related to various diseases. 
      The goal of our study was to identify whether the deregulation of serum miRNAs 
      was associated with T2DM and obesity. Twenty-five subjects with T2DM2, 25 healthy 
      controls, 25 subjects with obesity, and 25 subjects with T2DM combined with 
      obesity were included in the study. A total of 536 miRNA serum samples from these 
      four groups were studied by miRNA polymerase chain reaction (PCR) panels. Data 
      showed that miR-152 and miR-17 were significantly elevated in the OB group, 
      whereas miR-138 was significantly decreased in OB group when compared to 
      controls, T2DM, or T2DM+obesity group. In addition, level of MiR-593 was 
      significantly lower in T2DM group and T2DM+obesity group when compared with 
      controls. Further analysis revealed that the four miRNAs can be used as potential 
      biomarkers to distinguish obesity from T2DM, OB+T2DM, and healthy subjects. Our 
      study is one of the pioneer studies showing the differences in peripheral miRNA 
      level in obesity, T2DM and T2DM combined with obesity. The study results suggest 
      the potential utility of miRNAs in the prediction for obesity and T2DM.
CI  - (c) 2015 APMIS. Published by John Wiley & Sons Ltd.
FAU - Wu, Liangping
AU  - Wu L
AD  - Surgical Center of Thyroid Diabetes, General Hospital of Guangzhou Military 
      Command of PLA, Guangzhou, China.
FAU - Dai, Xiaojiang
AU  - Dai X
AD  - Surgical Center of Thyroid Diabetes, General Hospital of Guangzhou Military 
      Command of PLA, Guangzhou, China.
FAU - Zhan, Junfang
AU  - Zhan J
AD  - Health Management Center, Guangzhou First People's Hospital, Guangzhou Medical 
      College, Guangzhou, China.
FAU - Zhang, Yuxin
AU  - Zhang Y
AD  - Surgical Center of Thyroid Diabetes, General Hospital of Guangzhou Military 
      Command of PLA, Guangzhou, China.
FAU - Zhang, Hongbin
AU  - Zhang H
AD  - Surgical Center of Thyroid Diabetes, General Hospital of Guangzhou Military 
      Command of PLA, Guangzhou, China.
FAU - Zhang, Hongbing
AU  - Zhang H
AD  - Surgical Center of Thyroid Diabetes, General Hospital of Guangzhou Military 
      Command of PLA, Guangzhou, China.
FAU - Zeng, Songhua
AU  - Zeng S
AD  - Surgical Center of Thyroid Diabetes, General Hospital of Guangzhou Military 
      Command of PLA, Guangzhou, China.
FAU - Xi, Wenbin
AU  - Xi W
AD  - Surgical Center of Thyroid Diabetes, General Hospital of Guangzhou Military 
      Command of PLA, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150424
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Insulin)
RN  - 0 (MIRN138 microRNA, human)
RN  - 0 (MIRN152 microRNA, human)
RN  - 0 (MIRN17 microRNA, human)
RN  - 0 (MIRN593 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - Healthy Volunteers
MH  - Humans
MH  - Insulin/blood
MH  - MicroRNAs/*blood/genetics
MH  - Middle Aged
MH  - Obesity/blood/*genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - MicroRNA
OT  - diabetes
OT  - obesity
EDAT- 2015/04/29 06:00
MHDA- 2015/09/02 06:00
CRDT- 2015/04/28 06:00
PHST- 2015/01/18 00:00 [received]
PHST- 2015/02/23 00:00 [accepted]
PHST- 2015/04/28 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
AID - 10.1111/apm.12389 [doi]
PST - ppublish
SO  - APMIS. 2015 Jul;123(7):580-5. doi: 10.1111/apm.12389. Epub 2015 Apr 24.