PMID- 25912560 OWN - NLM STAT- MEDLINE DCOM- 20160125 LR - 20160730 IS - 1347-4820 (Electronic) IS - 1346-9843 (Linking) VI - 79 IP - 5 DP - 2015 TI - Adaptive servo-ventilation therapy for patients with chronic heart failure in a confirmatory, multicenter, randomized, controlled study. PG - 981-90 LID - 10.1253/circj.CJ-15-0221 [doi] AB - BACKGROUND: Adaptive servo-ventilation (ASV) therapy is expected to be novel nonpharmacotherapy with hemodynamic effects on patients with chronic heart failure (CHF), but sufficient evidence has not been obtained. METHODS AND RESULTS: A 24-week, open-label, randomized, controlled study was performed to confirm the cardiac function-improving effect of ASV therapy on CHF patients. At 39 institutions, 213 outpatients with CHF, whose left ventricular ejection fraction (LVEF) was <40% and who had mild to severe symptoms [New York Heart Association (NYHA) class: >/=II], were enrolled. After excluding 8 patients, 102 and 103 underwent ASV plus guideline-directed medical therapy (GDMT) [ASV group] and GDMT only [control group], respectively. The primary endpoint was LVEF, and the secondary endpoints were HF deterioration, B-type natriuretic peptide (BNP), and clinical composite response (CCR: NYHA class+HF deterioration). LVEF and BNP improved significantly at completion against the baseline values in the 2 groups. However, no significant difference was found between these groups. HF deterioration tended to be suppressed. The ASV group showed a significant improvement in CCR corroborated by significant improvements in NYHA class and ADL against the control group. CONCLUSIONS: Under the present study's conditions, ASV therapy was not superior to GDMT in the cardiac function-improving effect but showed a clinical status-improving effect, thus indicating a given level of clinical benefit. FAU - Momomura, Shin-Ichi AU - Momomura S AD - Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University. FAU - Seino, Yoshihiko AU - Seino Y FAU - Kihara, Yasuki AU - Kihara Y FAU - Adachi, Hitoshi AU - Adachi H FAU - Yasumura, Yoshio AU - Yasumura Y FAU - Yokoyama, Hiroyuki AU - Yokoyama H FAU - Wada, Hiroshi AU - Wada H FAU - Ise, Takayuki AU - Ise T FAU - Tanaka, Koichi AU - Tanaka K CN - SAVIOR-C investigators LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - Japan TA - Circ J JT - Circulation journal : official journal of the Japanese Circulation Society JID - 101137683 RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM CIN - Circ J. 2016;80(4):1047. PMID: 26948864 CIN - Circ J. 2016;80(4):1048. PMID: 26948865 MH - Aged MH - Aged, 80 and over MH - Chronic Disease MH - Female MH - *Heart Failure/blood/physiopathology/therapy MH - Humans MH - Male MH - Middle Aged MH - Natriuretic Peptide, Brain/*blood MH - Respiration, Artificial/*methods MH - *Stroke Volume FIR - Seino, Yoshihiko IR - Seino Y FIR - Kihara, Yasuki IR - Kihara Y FIR - Adachi, Hitoshi IR - Adachi H FIR - Yasumura, Yoshio IR - Yasumura Y FIR - Yokoyama, Hiroyuki IR - Yokoyama H FIR - Yoshida, Kiyoshi IR - Yoshida K FIR - Hayashida, Akihiro IR - Hayashida A FIR - Sato, Naoki IR - Sato N FIR - Hozumi, Takeshi IR - Hozumi T FIR - Yamashita, Hiroshi IR - Yamashita H FIR - Yamamoto, Kazuhiro IR - Yamamoto K FIR - Asanoi, Hidetsugu IR - Asanoi H FIR - Ando, Shinichi IR - Ando S FIR - Ito, Masaaki IR - Ito M FIR - Inoue, Hiroshi IR - Inoue H FIR - Ogawa, Hisao IR - Ogawa H FIR - Sata, Masataka IR - Sata M FIR - Shimokawa, Hiroaki IR - Shimokawa H FIR - Tsutsui, Hiroyuki IR - Tsutsui H FIR - Tomoike, Hitonobu IR - Tomoike H FIR - Masuyama, Tohru IR - Masuyama T FIR - Murohara, Toyoaki IR - Murohara T FIR - Yoshikawa, Tsutomu IR - Yoshikawa T FIR - Ueshima, Kenji IR - Ueshima K FIR - Momomura, S IR - Momomura S FIR - Wada, H IR - Wada H FIR - Sugawara, Y IR - Sugawara Y FIR - Ikeda, N IR - Ikeda N FIR - Tsurumaki, Y IR - Tsurumaki Y FIR - Sata, M IR - Sata M FIR - Ise, T IR - Ise T FIR - Yagi, S IR - Yagi S FIR - Tanaka, K IR - Tanaka K FIR - Kobayashi, K IR - Kobayashi K FIR - Orita, Y IR - Orita Y FIR - Taniguchi, Y IR - Taniguchi Y FIR - Oishi, S IR - Oishi S FIR - Yokoi, K IR - Yokoi K FIR - Kihara, Y IR - Kihara Y FIR - Oda, N IR - Oda N FIR - Hidaka, T IR - Hidaka T FIR - Kajikawa, M IR - Kajikawa M FIR - Watanabe, Y IR - Watanabe Y FIR - Yokoyama, H IR - Yokoyama H FIR - Anzai, T IR - Anzai T FIR - Nakamura, K IR - Nakamura K FIR - Sugano, Y IR - Sugano Y FIR - Yasuda, M IR - Yasuda M FIR - Fukumitsu, M IR - Fukumitsu M FIR - Nakayama, T IR - Nakayama T FIR - Kasai, T IR - Kasai T FIR - Ito, M IR - Ito M FIR - Kumagai, N IR - Kumagai N FIR - Sato, Y IR - Sato Y FIR - Dohi, K IR - Dohi K FIR - Tanimura, M IR - Tanimura M FIR - Watanabe, K IR - Watanabe K FIR - Haruki, N IR - Haruki N FIR - Seino, Y IR - Seino Y FIR - Inami, T IR - Inami T FIR - Kato, T IR - Kato T FIR - Hiraiwa, H IR - Hiraiwa H FIR - Kondo, T IR - Kondo T FIR - Ishihara, T IR - Ishihara T FIR - Yanagihara, K IR - Yanagihara K FIR - Hara, M IR - Hara M FIR - Jo, H IR - Jo H FIR - Ashihara, T IR - Ashihara T FIR - Kubo, T IR - Kubo T FIR - Muramatsu, T IR - Muramatsu T FIR - Nakano, S IR - Nakano S FIR - Yoshikawa, T IR - Yoshikawa T FIR - Sasaki, S IR - Sasaki S FIR - Iguch, N IR - Iguch N FIR - Nagayama, M IR - Nagayama M FIR - Izumi, Y IR - Izumi Y FIR - Adachi, H IR - Adachi H FIR - Takamatsu, H IR - Takamatsu H FIR - Inoue, H IR - Inoue H FIR - Joho, S IR - Joho S FIR - Asanoi, H IR - Asanoi H FIR - Harada, D IR - Harada D FIR - Ishise, H IR - Ishise H FIR - Oshitani, K IR - Oshitani K FIR - Ueno, H IR - Ueno H FIR - Sunagawa, K IR - Sunagawa K FIR - Higo, T IR - Higo T FIR - Nishizaka, M IR - Nishizaka M FIR - Ogawa, H IR - Ogawa H FIR - Kojima, S IR - Kojima S FIR - Mizuno, K IR - Mizuno K FIR - Fukuma, N IR - Fukuma N FIR - Kubota, Y IR - Kubota Y FIR - Takahashi, H IR - Takahashi H FIR - Adachi, T IR - Adachi T FIR - Kimura, T IR - Kimura T FIR - Hakuno, D IR - Hakuno D FIR - Isobe, S IR - Isobe S FIR - Akita, K IR - Akita K FIR - Masaki, N IR - Masaki N FIR - Yasu, T IR - Yasu T FIR - Ohya, Y IR - Ohya Y FIR - Nakagawa, Y IR - Nakagawa Y FIR - Kondo, H IR - Kondo H FIR - Shimokawa, H IR - Shimokawa H FIR - Nochioka, K IR - Nochioka K FIR - Fukumoto, Y IR - Fukumoto Y FIR - Murohara, T IR - Murohara T FIR - Hirashiki, A IR - Hirashiki A FIR - Okumura, T IR - Okumura T FIR - Watarai, M IR - Watarai M FIR - Koyasu, M IR - Koyasu M FIR - Miura, A IR - Miura A FIR - Ishikawa, S IR - Ishikawa S FIR - Sakanoue, Y IR - Sakanoue Y FIR - Kanemori, T IR - Kanemori T FIR - Nakamura, Y IR - Nakamura Y FIR - Fujita, M IR - Fujita M FIR - Iwabuchi, M IR - Iwabuchi M FIR - Ando, K IR - Ando K FIR - Mazaki, T IR - Mazaki T FIR - Kono, T IR - Kono T FIR - Itamoto, C IR - Itamoto C FIR - Miura, H IR - Miura H FIR - Izumi, T IR - Izumi T FIR - Yasumura, Y IR - Yasumura Y FIR - Hamano, G IR - Hamano G FIR - Fukuda, K IR - Fukuda K FIR - Kohno, T IR - Kohno T FIR - Mogi, S IR - Mogi S FIR - Yamada, T IR - Yamada T FIR - Kadokami, T IR - Kadokami T FIR - Hosokawa, K IR - Hosokawa K FIR - Touyama, T IR - Touyama T FIR - Okayama, H IR - Okayama H FIR - Hiasa, G IR - Hiasa G FIR - Tsutsui, H IR - Tsutsui H FIR - Yamada, S IR - Yamada S FIR - Inada, T IR - Inada T FIR - Ito, H IR - Ito H EDAT- 2015/04/29 06:00 MHDA- 2016/01/26 06:00 CRDT- 2015/04/28 06:00 PHST- 2015/04/28 06:00 [entrez] PHST- 2015/04/29 06:00 [pubmed] PHST- 2016/01/26 06:00 [medline] AID - 10.1253/circj.CJ-15-0221 [doi] PST - ppublish SO - Circ J. 2015;79(5):981-90. doi: 10.1253/circj.CJ-15-0221.