PMID- 25913152 OWN - NLM STAT- MEDLINE DCOM- 20150925 LR - 20221207 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 140 DP - 2015 Jul TI - Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers. PG - 335-44 LID - S0013-9351(15)00115-2 [pii] LID - 10.1016/j.envres.2015.03.037 [doi] AB - BACKGROUND: Exposure to persistent organic pollutants (POPs) is associated with increased diabetes risk, although the mechanism of action is not well delineated. METHODS: We investigated established diabetes biomarkers that could implicate potential mechanistic pathways, including C-reactive protein (CRP), a marker of systemic inflammation; gamma glutamyl transferase (GGT), a liver enzyme associated with oxidative stress; and adiponectin, an adipokine modulating glucose regulation and fatty acid oxidation. These biomarkers as well as hemoglobin A1c (HA1c), and POPs [polychlorinated biphenyls (PCBs), p,p-dichlorodiphenyldichloroethylene (DDE) and polybrominated diphenyl ethers (PBDEs)] were measured in a cohort of Great Lakes sport caught fish (GLSCF) consumers. We examined associations of POPs and fish consumption with HA1c and incident diabetes, and evaluated mediation and moderation by the diabetes biomarkers. RESULTS: Odds of incident diabetes were elevated with exposure to DDE and PCBs. DDE and PCB 118 were positively, and fish meals were inversely, associated with HA1c. CRP was inversely associated with saltwater and total fish meals, particularly in persons with higher adiposity, but did not mediate the associations of fish meals with HA1c. There were few associations of POPs with adiponectin, CRP and GGT, with the exception of positive associations of PCB 118 with GGT, PBDEs with GGT in older persons, and PBDEs with adiponectin. Adiponectin, CRP and GGT did not mediate associations of DDE and PCBs with HA1c or incident diabetes. However, the association of DDE with HA1c was stronger in persons with higher CRP, GGT and BMI, and lower adiponectin, while the association of PCB 118 with HA1c was stronger in persons with higher GGT. CONCLUSIONS: These findings suggest that adiponectin, CRP and GGT did not mediate effects of POPs on diabetes or HA1c. However, POPs may have stronger effects on blood glucose in persons at higher risk for diabetes. CI - Copyright (c) 2015 Elsevier Inc. All rights reserved. FAU - Turyk, Mary AU - Turyk M AD - University of Illinois at Chicago, Division of Epidemiology and Biostatistics, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60612, United States. Electronic address: mturyk1@uic.edu. FAU - Fantuzzi, Giamila AU - Fantuzzi G AD - University of Illinois at Chicago, Department of Kinesiology and Nutrition, College of Applied Health Sciences, 1919 W. Taylor Street, Chicago, IL 60612, United States. FAU - Persky, Victoria AU - Persky V AD - University of Illinois at Chicago, Division of Epidemiology and Biostatistics, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60612, United States. FAU - Freels, Sally AU - Freels S AD - University of Illinois at Chicago, Division of Epidemiology and Biostatistics, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60612, United States. FAU - Lambertino, Anissa AU - Lambertino A AD - University of Illinois at Chicago, Division of Epidemiology and Biostatistics, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60612, United States. FAU - Pini, Maria AU - Pini M AD - University of Illinois at Chicago, Department of Kinesiology and Nutrition, College of Applied Health Sciences, 1919 W. Taylor Street, Chicago, IL 60612, United States; Universite Pierre et Marie Curie-Paris6, Centre de Recherche des Cordeliers, UMRS 872, Paris F-75006, France; Institute of Cardiometabolism and Nutrition (ICAN), Pitie-Salpetriere Hospital, Paris F-75013, France. FAU - Rhodes, Davina H AU - Rhodes DH AD - University of Illinois at Chicago, Department of Kinesiology and Nutrition, College of Applied Health Sciences, 1919 W. Taylor Street, Chicago, IL 60612, United States; Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, United States. FAU - Anderson, Henry A AU - Anderson HA AD - Wisconsin Division of Public Health, 1 W. Wilson St., Room 150, Madison, WI 53702, United States. LA - eng GR - R21 ES017121/ES/NIEHS NIH HHS/United States GR - R21ES017121/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20150422 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin A) RN - 0 (Organic Chemicals) RN - 0 (Water Pollutants, Chemical) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Animals MH - Biomarkers/*blood MH - Body Mass Index MH - Cohort Studies MH - Diabetes Mellitus/*epidemiology MH - Environmental Exposure MH - Female MH - *Fishes MH - Glycated Hemoglobin/metabolism MH - Humans MH - Male MH - Middle Aged MH - Organic Chemicals/*analysis/toxicity MH - *Recreation MH - Risk Factors MH - Water Pollutants, Chemical/*analysis/toxicity PMC - PMC4492847 MID - NIHMS684166 OTO - NOTNLM OT - Adiponectin OT - C-reactive protein OT - DDE OT - Diabetes OT - Fish consumption OT - Gamma glutamyl transferase OT - PCBs OT - Persistent organic pollutants EDAT- 2015/04/29 06:00 MHDA- 2015/09/26 06:00 PMCR- 2016/07/01 CRDT- 2015/04/28 06:00 PHST- 2015/01/23 00:00 [received] PHST- 2015/03/11 00:00 [revised] PHST- 2015/03/30 00:00 [accepted] PHST- 2015/04/28 06:00 [entrez] PHST- 2015/04/29 06:00 [pubmed] PHST- 2015/09/26 06:00 [medline] PHST- 2016/07/01 00:00 [pmc-release] AID - S0013-9351(15)00115-2 [pii] AID - 10.1016/j.envres.2015.03.037 [doi] PST - ppublish SO - Environ Res. 2015 Jul;140:335-44. doi: 10.1016/j.envres.2015.03.037. Epub 2015 Apr 22.