PMID- 25913253
OWN - NLM
STAT- MEDLINE
DCOM- 20160128
LR  - 20181202
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 57
DP  - 2015 Jul
TI  - Nano-assemblies of J-aggregates based on a NIR dye as a multifunctional drug 
      carrier for combination cancer therapy.
PG  - 84-92
LID - S0142-9612(15)00348-8 [pii]
LID - 10.1016/j.biomaterials.2015.04.001 [doi]
AB  - The combination of chemotherapy with photothermal therapy, which may lead to 
      improved therapeutic efficacies and reduced side effects of conventional 
      chemotherapy, would require safe drug delivery systems (DDSs) with strong 
      near-infrared (NIR) absorbance, efficient drug loading, and effective tumor 
      homing ability. Herein, we fabricate nano-assemblies containing J-aggregates of a 
      NIR dye, IR825, for drug delivery and combined photothermal & chemotherapy of 
      cancer. It is found that IR825 could be complexed with a low-molecular-weight 
      cationic polymer polyethylenimine (PEI), forming IR825@PEI J-aggregates with 
      greatly enhanced NIR absorbance red-shifted to 915 nm. Those nano-assemblies of 
      J-aggregates are further modified with polyethylene glycol (PEG), obtaining 
      IR825@PEI-PEG nano-complex which exhibits great dispersity in physiological 
      solutions, excellent photostability, and is able to efficiently load 
      chemotherapeutic drug doxorubicin (DOX) via a unique strategy different from drug 
      loading in conventional amphiphilic polymer-based DDSs. In vivo animal 
      experiments uncover that IR825@PEI-PEG/DOX upon intravenous injection into 
      tumor-bearing mice shows rather high tumor uptake as illustrated by photoacoustic 
      imaging. In vivo combined photothermal & chemotherapy is then carried out, 
      demonstrating great synergistic anti-tumor therapeutic effect remarkably superior 
      to those achieved by the respective mono-therapies. Hence, we present a novel 
      type of nanoscale DDSs based on nano-assemblies of small molecules without 
      involving amphiphilic polymers, promising for imaging-guided combination cancer 
      therapy.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Song, Xuejiao
AU  - Song X
AD  - Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation 
      Center of Suzhou Nano Science and Technology, The Jiangsu Key Laboratory for 
      Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 
      215123, China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation 
      Center of Suzhou Nano Science and Technology, The Jiangsu Key Laboratory for 
      Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 
      215123, China.
FAU - Liang, Chao
AU  - Liang C
AD  - Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation 
      Center of Suzhou Nano Science and Technology, The Jiangsu Key Laboratory for 
      Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 
      215123, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation 
      Center of Suzhou Nano Science and Technology, The Jiangsu Key Laboratory for 
      Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 
      215123, China.
FAU - Gong, Hua
AU  - Gong H
AD  - Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation 
      Center of Suzhou Nano Science and Technology, The Jiangsu Key Laboratory for 
      Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 
      215123, China.
FAU - Liu, Zhuang
AU  - Liu Z
AD  - Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation 
      Center of Suzhou Nano Science and Technology, The Jiangsu Key Laboratory for 
      Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 
      215123, China. Electronic address: zliu@suda.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150424
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Benzoates)
RN  - 0 (Drug Carriers)
RN  - 0 (IR825 dye)
RN  - 0 (Indoles)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 80168379AG (Doxorubicin)
RN  - 9002-98-6 (Polyethyleneimine)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/*administration & dosage/pharmacokinetics/therapeutic 
      use
MH  - Benzoates/*administration & dosage/pharmacokinetics/therapeutic use
MH  - Breast/drug effects/*pathology
MH  - Breast Neoplasms/pathology/*therapy
MH  - Cell Line, Tumor
MH  - Combined Modality Therapy
MH  - Doxorubicin/*administration & dosage/pharmacokinetics/therapeutic use
MH  - Drug Carriers/*chemistry
MH  - Female
MH  - Humans
MH  - Hyperthermia, Induced
MH  - Indoles/*administration & dosage/pharmacokinetics/therapeutic use
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nanostructures/chemistry
MH  - Photochemotherapy
MH  - Polyethylene Glycols/chemistry
MH  - Polyethyleneimine/*chemistry
OTO - NOTNLM
OT  - Combination therapy
OT  - Drug delivery systems
OT  - J-aggregates
OT  - Organic NIR dye
OT  - Photothermal therapy
EDAT- 2015/04/29 06:00
MHDA- 2016/01/29 06:00
CRDT- 2015/04/28 06:00
PHST- 2015/03/14 00:00 [received]
PHST- 2015/03/31 00:00 [revised]
PHST- 2015/04/02 00:00 [accepted]
PHST- 2015/04/28 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2016/01/29 06:00 [medline]
AID - S0142-9612(15)00348-8 [pii]
AID - 10.1016/j.biomaterials.2015.04.001 [doi]
PST - ppublish
SO  - Biomaterials. 2015 Jul;57:84-92. doi: 10.1016/j.biomaterials.2015.04.001. Epub 
      2015 Apr 24.