PMID- 2591344
OWN - NLM
STAT- MEDLINE
DCOM- 19900124
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 30
IP  - 6
DP  - 1989 Nov-Dec
TI  - Modulation of generalized spike-and-wave discharges during sleep by cyclic 
      alternating pattern.
PG  - 772-81
AB  - Because arousal plays a critical role in activation of epileptic phenomena, we 
      analyzed the behavior of interictal generalized spike-and-waves (S-W) during the 
      two recently identified modalities of arousal control during NREM sleep: (a) the 
      cyclic alternating pattern (CAP), expressed by successive biphasic (phase A and 
      phase B) fluctuations of arousal; and (b) non-CAP (NCAP), characterized by 
      prolonged stable periods of EEG and arousal level. Within the single NREM stages, 
      phase A consists of clusters of phasic events associated with transient arousal 
      activation, whereas phase B is represented by the periodic reappearance of the 
      EEG background and reflects a rebound inhibitory condition. The polysomnograms of 
      10 subjects with a wide age range and affected by primary generalized epilepsy 
      displayed significant differences (all at p less than 0.01) between the spike 
      indexes (S-W/min) of CAP (2.9) and NCAP (1.3), of phase A (7.4) and phase B 
      (0.3), and of NCAP and phase B. For distribution of S-W, a significant prevalence 
      of EEG paroxysms was detected during CAP as compared with NCAP (68 vs. 32%, p 
      less than 0.001), and 93% of all the interictal bursts that occurred in CAP 
      occurred in phase A (p less than 0.001). Our data stress the arousal-dependent 
      influence of CAP and NCAP on modulation of generalized epileptic mechanisms 
      during sleep.
FAU - Terzano, M G
AU  - Terzano MG
AD  - Department of Neurology, University of Parma, Italy.
FAU - Parrino, L
AU  - Parrino L
FAU - Anelli, S
AU  - Anelli S
FAU - Halasz, P
AU  - Halasz P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arousal/physiology
MH  - Child
MH  - *Electroencephalography
MH  - Epilepsy/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sleep/*physiology
MH  - Sleep Stages/physiology
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1111/j.1528-1157.1989.tb05337.x [doi]
PST - ppublish
SO  - Epilepsia. 1989 Nov-Dec;30(6):772-81. doi: 10.1111/j.1528-1157.1989.tb05337.x.