PMID- 25913636
OWN - NLM
STAT- MEDLINE
DCOM- 20161216
LR  - 20161217
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 323
DP  - 2016 May 26
TI  - Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and 
      pannexin1.
PG  - 207-21
LID - S0306-4522(15)00376-0 [pii]
LID - 10.1016/j.neuroscience.2015.04.035 [doi]
AB  - The World Health Organization has predicted that by 2040 neurodegenerative 
      diseases will overtake cancer to become the world's second leading cause of death 
      after cardiovascular disease. This has sparked the development of several 
      European and American brain research initiatives focusing on elucidating the 
      underlying cellular and molecular mechanisms of neurodegenerative diseases. 
      Connexin (Cx) and pannexin (Panx) membrane channel proteins are conduits through 
      which neuronal, glial, and vascular tissues interact. In the brain, this 
      interaction is highly critical for homeostasis and brain repair after injury. 
      Understanding the molecular mechanisms by which these membrane channels function, 
      in health and disease, might be particularly influential in establishing 
      conceptual frameworks to develop new therapeutics against Cx and Panx channels. 
      This review focuses on current insights and emerging concepts, particularly the 
      impact of connexin43 and pannexin1, under neuroprotective and neurodegenerative 
      conditions within the context of astrocytes.
CI  - Crown Copyright (c) 2015. Published by Elsevier Ltd. All rights reserved.
FAU - Freitas-Andrade, M
AU  - Freitas-Andrade M
AD  - Department of Cellular and Physiological Sciences, The Life Science Institute, 
      University of British Columbia, Vancouver, British Columbia, Canada.
FAU - Naus, C C
AU  - Naus CC
AD  - Department of Cellular and Physiological Sciences, The Life Science Institute, 
      University of British Columbia, Vancouver, British Columbia, Canada. Electronic 
      address: christian.naus@ubc.ca.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150423
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Connexin 43)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Astrocytes/*metabolism
MH  - Connexin 43/genetics/*metabolism
MH  - Humans
MH  - Nerve Degeneration/*metabolism
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Neurodegenerative Diseases/*metabolism
MH  - Neuroprotection/*physiology
OTO - NOTNLM
OT  - astrocytes
OT  - connexin43
OT  - neurodegeneration
OT  - pannexin1
EDAT- 2015/04/29 06:00
MHDA- 2016/12/17 06:00
CRDT- 2015/04/28 06:00
PHST- 2015/01/11 00:00 [received]
PHST- 2015/04/13 00:00 [revised]
PHST- 2015/04/15 00:00 [accepted]
PHST- 2015/04/28 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2016/12/17 06:00 [medline]
AID - S0306-4522(15)00376-0 [pii]
AID - 10.1016/j.neuroscience.2015.04.035 [doi]
PST - ppublish
SO  - Neuroscience. 2016 May 26;323:207-21. doi: 10.1016/j.neuroscience.2015.04.035. 
      Epub 2015 Apr 23.