PMID- 25916568
OWN - NLM
STAT- MEDLINE
DCOM- 20160624
LR  - 20161222
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 12
IP  - 8
DP  - 2015 Aug
TI  - Late gadolinium enhancement of cardiac magnetic resonance imaging indicates 
      abnormalities of time-domain T-wave alternans in hypertrophic cardiomyopathy with 
      ventricular tachycardia.
PG  - 1747-55
LID - S1547-5271(15)00495-6 [pii]
LID - 10.1016/j.hrthm.2015.04.028 [doi]
AB  - BACKGROUND: The presence of myocardial scar detected by late gadolinium 
      enhancement (LGE) on cardiac magnetic resonance (CMR) imaging has been described 
      as a good independent predictor of mortality in patients with hypertrophic 
      cardiomyopathy (HCM). Time-domain T-wave alternans (TWA) is also a potential 
      predictor of cardiac mortality in patients with left ventricular dysfunction. 
      OBJECTIVE: The purpose of this study was to elucidate the relationship between 
      LGE distribution and TWA in patients with HCM. METHODS: CMR and TWA analyses 
      using Holter monitoring were performed in 42 patients with HCM. The average 
      transmural extent of LGE was scored as 1-4 in each segment, and the sum of the 
      LGE scores (total LGE score) was calculated for each patient. The correlation 
      between the maximal time-domain TWA voltage and LGE findings was analyzed, and 
      the differences in time-domain TWA voltage, total LGE score, and cardiac function 
      assessed by CMR imaging in the presence or absence of ventricular tachycardia 
      (VT) were also compared. RESULTS: The total LGE score was significantly and 
      positively correlated with the maximal time-domain TWA voltage (r = 0.59; P < 
      .001). Furthermore, the total LGE score and maximal time-domain TWA voltage were 
      significantly greater in patients who had episodes of VT (n = 21) than in those 
      without VT (23 +/- 7 vs. 10 +/- 8; P < .001 and 87 +/- 26 muV vs. 62 +/- 12 muV; P < .001, 
      respectively). However, the left ventricular ejection fraction did not 
      statistically differ between patients with VT and those without VT (56% +/- 14% vs. 
      61% +/- 7%; P = .102). CONCLUSION: The magnitude of the localized LGE was 
      significantly correlated with abnormalities in ventricular repolarization as 
      assessed by TWA and QT dispersion.
CI  - Copyright (c) 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Sakamoto, Naka
AU  - Sakamoto N
AD  - Department of Cardiology.
FAU - Sato, Nobuyuki
AU  - Sato N
AD  - Department of Cardiology. Electronic address: nsato@asahikawa-med.ac.jp.
FAU - Oikawa, Kensuke
AU  - Oikawa K
AD  - Department of Pathology.
FAU - Karim Talib, Ahmed
AU  - Karim Talib A
AD  - Department of Cardiology.
FAU - Sugiyama, Eitaro
AU  - Sugiyama E
AD  - Department of Cardiology.
FAU - Minoshima, Akiho
AU  - Minoshima A
AD  - Department of Cardiology.
FAU - Tanabe, Yasuko
AU  - Tanabe Y
AD  - Department of Cardiology.
FAU - Takeuchi, Toshiharu
AU  - Takeuchi T
AD  - Department of Cardiology.
FAU - Akasaka, Kazumi
AU  - Akasaka K
AD  - Department of Cardiology; Department of Pathology.
FAU - Saijo, Yasuaki
AU  - Saijo Y
AD  - Division of Community Medicine and Epidemiology, Department of Health Science, 
      Asahikawa Medical University, Asahikawa, Japan.
FAU - Kawamura, Yuichiro
AU  - Kawamura Y
AD  - Department of Cardiology.
FAU - Hasebe, Naoyuki
AU  - Hasebe N
AD  - Department of Cardiology.
LA  - eng
PT  - Journal Article
DEP - 20150423
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/complications/mortality/*pathology
MH  - *Contrast Media
MH  - *Electrocardiography
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Tachycardia, Ventricular/etiology/mortality/*physiopathology
MH  - Time Factors
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - T-wave alternans
OT  - Ventricular fibrillation
OT  - Ventricular tachycardia
EDAT- 2015/04/29 06:00
MHDA- 2016/06/25 06:00
CRDT- 2015/04/29 06:00
PHST- 2014/08/28 00:00 [received]
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2016/06/25 06:00 [medline]
AID - S1547-5271(15)00495-6 [pii]
AID - 10.1016/j.hrthm.2015.04.028 [doi]
PST - ppublish
SO  - Heart Rhythm. 2015 Aug;12(8):1747-55. doi: 10.1016/j.hrthm.2015.04.028. Epub 2015 
      Apr 23.