PMID- 25916642
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20181202
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 44
IP  - 2
DP  - 2015 Feb
TI  - [Prognostic significance of MYCN amplification in children neuroblastic tumors].
PG  - 111-7
AB  - OBJECTIVE: To summarize the clinicopathologic features of neuroblastic tumors 
      (NT), and to explore the prognostic significance of MYCN amplification in NT. 
      METHODS: The clinicopathologic data of 267 NT were reviewed. MYCN gene 
      amplification was detected by fluorescence in situ hybridization (FISH) in 119 
      cases and the relationship with pathological characteristics and prognostic 
      significance were analyzed. RESULTS: The study included 267 cases of children NT 
      from patients aged from 1 day to 13 years (median 27 months). The male to female 
      ratio was 1.43. There were 38 cases (14.2%), 43 cases (16.1%), 71 cases (26.6%), 
      and 115 cases (43.1%) of INSS stages I, II, III and IV respectively.Favorable 
      histology group had 157 cases (59.9%); unfavorable histology group had 110 cases 
      (40.1%).Of the 119 NT cases with MYCN FISH performed, 18 cases (15.1%) showed 
      amplification and the signal ratio of MYCN to CEP2 was 4.08-43.29. One hundred 
      and one cases of non-amplified MYCN included MYCN gain in 79 cases (66.3%) and 
      MYCN negative in 22 cases (18.5%). MYCN expression showed significant difference 
      (P = 0.000) between ages, gender, NT type and MKI, but not INPC and clinical 
      stage (P > 0.05).Of the 18 cases with MYCN amplification, 3 were 
      undifferentiated, and 15 poorly differentiated; 17 had high MKI and one moderate 
      MKI. All 18 cases were in unfavorable histology group; the overall survival rate 
      was 3/18, with an average survival time of (17.9 +/- 2.4) months.Of the 101 MYCN 
      non-amplification cases, the overall survival rate was 68.3% (69/101), with an 
      average survival time of (29.8 +/- 1.3) months. Survival analysis showed the cases 
      with MYCN amplification had worse prognosis (P < 0.05). CONCLUSIONS: NT were 
      commonly diagnosed in early ages and easily to metastasize. Most of cases with 
      favorable histology. The cases of MYCN amplification showed unfavorable 
      histology, and the majority cases with high MKI; The patients with MYCN gene 
      amplification had poor prognosis.
FAU - Niu, Huilin
AU  - Niu H
AD  - Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou 
      510623, China. E-mail: aniuemail@163.com.
FAU - Xu, Tao
AU  - Xu T
FAU - Wang, Fenghua
AU  - Wang F
FAU - Chen, Zhengrong
AU  - Chen Z
FAU - Gao, Qiu
AU  - Gao Q
FAU - Yi, Peng
AU  - Yi P
FAU - Xia, Jianqing
AU  - Xia J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (MYCN protein, human)
RN  - 0 (N-Myc Proto-Oncogene Protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins)
SB  - IM
MH  - Adolescent
MH  - Cell Differentiation
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - N-Myc Proto-Oncogene Protein
MH  - Neuroblastoma/*genetics/mortality/pathology
MH  - Nuclear Proteins/*genetics
MH  - Oncogene Proteins/*genetics
MH  - Prognosis
MH  - Survival Analysis
MH  - Survival Rate
EDAT- 2015/04/29 06:00
MHDA- 2015/07/15 06:00
CRDT- 2015/04/29 06:00
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2015 Feb;44(2):111-7.