PMID- 25916883
OWN - NLM
STAT- MEDLINE
DCOM- 20151019
LR  - 20220410
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 597
DP  - 2015 Jun 15
TI  - Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of 
      chronic fluoxetine treatment in a mouse model of anxiety/depression.
PG  - 121-6
LID - S0304-3940(15)00335-3 [pii]
LID - 10.1016/j.neulet.2015.04.036 [doi]
AB  - Several studies have shown that Nrf2, a major redox-sensitive transcription 
      factor involved in the cellular defense against oxidative stress, increases 
      susceptibility to depressive-like behavior. However, little is known about the 
      influence of antidepressant drugs on Nrf2 signaling and expression of its target 
      genes (GCLC, NQO1, HO-1) in the brain. We found that chronic treatment of a mouse 
      model of anxiety/depression (CORT model) with a selective serotonin reuptake 
      inhibitor (SSRI, fluoxetine, 18mg/kg/day) reversed CORT-induced 
      anxiety/depression-like behavior in mice. Chronic fluoxetine treatment restored 
      CORT-induced decreases in Nrf2 protein levels and its target genes in the cortex 
      and hippocampus. Furthermore, we found that chronic fluoxetine also increased 
      brain derived neurotrophic factor (BDNF) protein levels in cortex and hippocampus 
      of CORT-treated Nrf2 knockout mice (KO, Nrf2(-/-)). Taken together, these data 
      suggest that Nrf2 signaling contributes to fluoxetine-induced neuroprotection via 
      an unexpected mechanism involving 5-HT transporter SERT blockade, and not through 
      enhancement of BDNF expression.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Mendez-David, Indira
AU  - Mendez-David I
AD  - Univ Paris Sud, INSERM UMR S 1178, Fac Pharmacie, Univ Paris-Saclay, 
      Chatenay-Malabry, F-92290, France.
FAU - Tritschler, Laurent
AU  - Tritschler L
AD  - Univ Paris Sud, INSERM UMR S 1178, Fac Pharmacie, Univ Paris-Saclay, 
      Chatenay-Malabry, F-92290, France.
FAU - Ali, Zeina El
AU  - Ali ZE
AD  - Univ Paris Sud, INSERM UMR 996, Fac Pharmacie, Univ Paris-Saclay, 
      Chatenay-Malabry, F-92290, France.
FAU - Damiens, Marie-Helene
AU  - Damiens MH
AD  - Univ Paris Sud, INSERM UMR 996, Fac Pharmacie, Univ Paris-Saclay, 
      Chatenay-Malabry, F-92290, France.
FAU - Pallardy, Marc
AU  - Pallardy M
AD  - Univ Paris Sud, INSERM UMR 996, Fac Pharmacie, Univ Paris-Saclay, 
      Chatenay-Malabry, F-92290, France.
FAU - David, Denis J
AU  - David DJ
AD  - Univ Paris Sud, INSERM UMR S 1178, Fac Pharmacie, Univ Paris-Saclay, 
      Chatenay-Malabry, F-92290, France.
FAU - Kerdine-Romer, Saadia
AU  - Kerdine-Romer S
AD  - Univ Paris Sud, INSERM UMR 996, Fac Pharmacie, Univ Paris-Saclay, 
      Chatenay-Malabry, F-92290, France.
FAU - Gardier, Alain M
AU  - Gardier AM
AD  - Univ Paris Sud, INSERM UMR S 1178, Fac Pharmacie, Univ Paris-Saclay, 
      Chatenay-Malabry, F-92290, France. Electronic address: alain.gardier@u-psud.fr.
LA  - eng
PT  - Journal Article
DEP - 20150424
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Nfe2l2 protein, mouse)
RN  - 01K63SUP8D (Fluoxetine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology/therapeutic use
MH  - Anxiety/*drug therapy/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Corticosterone/pharmacology
MH  - Depression/*drug therapy/metabolism
MH  - Fluoxetine/*pharmacology/therapeutic use
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - NF-E2-Related Factor 2/genetics/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - Animal model of anxiety/depression
OT  - Antidepressant
OT  - BDNF
OT  - Nrf2 pathway
EDAT- 2015/04/29 06:00
MHDA- 2015/10/20 06:00
CRDT- 2015/04/29 06:00
PHST- 2015/02/23 00:00 [received]
PHST- 2015/04/22 00:00 [revised]
PHST- 2015/04/23 00:00 [accepted]
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2015/10/20 06:00 [medline]
AID - S0304-3940(15)00335-3 [pii]
AID - 10.1016/j.neulet.2015.04.036 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Jun 15;597:121-6. doi: 10.1016/j.neulet.2015.04.036. Epub 
      2015 Apr 24.