PMID- 25917747
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20181113
IS  - 1572-8595 (Electronic)
IS  - 1383-875X (Linking)
VI  - 43
IP  - 2
DP  - 2015 Aug
TI  - Long-term monitoring of respiratory rate in patients with heart failure: the 
      Multiparametric Heart Failure Evaluation in Implantable 
      Cardioverter-Defibrillator Patients (MULTITUDE-HF) study.
PG  - 135-44
LID - 10.1007/s10840-015-0007-3 [doi]
AB  - BACKGROUND: Monitoring respiratory rate (RR) is recommended at the time of 
      hospital presentation for acute decompensation in heart failure (HF). 
      Device-based continuous monitoring of RR may be helpful for diagnostic and 
      prognostic stratification after implantable cardioverter-defibrillator (ICD) 
      implantation. This study was undertaken to analyze short- and long-term changes 
      in ICD-measured RR and to relate RR with the patient's clinical status and the 
      occurrence of HF events. METHODS: One hundred twenty-four consecutive HF patients 
      who received ICD endowed with this diagnostic capability (Boston Scientific Inc., 
      Natick, MA, USA) were prospectively enrolled. Patients were followed up for 12 
      months. RESULTS: At the baseline, the proportion of New York Heart Association 
      (NYHA) class III-IV was higher among patients with daily maximum RR >27 
      breaths/min (third tertile) than those with <24 breaths/min (first tertile) (43 
      vs. 23%, p < 0.05). Moreover, the ejection fraction was lower (27 +/- 7 vs. 
      34 +/- 8%, p < 0.05). In patients with HF hospitalizations (33 events) and urgent 
      visits for HF (15 events), the weekly average of RR calculated over the 7 days 
      preceding hospital accesses did not differ from values recorded at the baseline 
      and before scheduled follow-up visits. However, the weekly variation in RR (i.e., 
      the difference between maximum and minimum values collected over the week) was 
      significantly higher prior to hospitalization (p < 0.05). A weekly variation >3 
      breaths/min in maximum RR predicted an impending hospital admission for HF with 
      sensitivity of 73 % and specificity of 57%. CONCLUSIONS: In this study, elevated 
      values of ICD-monitored RR identified patients with worse functional status and 
      lower systolic function. The weekly variation in RR increased before HF 
      exacerbation. This monitoring technology may represent a useful tool in the 
      clinical management of patients with HF.
FAU - Forleo, Giovanni B
AU  - Forleo GB
AD  - Cardiology, University of Tor Vergata, Viale Oxford, 81., 00133, Rome, Italy, 
      forleo@me.com.
FAU - Santini, Luca
AU  - Santini L
FAU - Campoli, Massimiliano
AU  - Campoli M
FAU - Malavasi, Mario
AU  - Malavasi M
FAU - Scaccia, Alberto
AU  - Scaccia A
FAU - Menichelli, Maurizio
AU  - Menichelli M
FAU - Riva, Umberto
AU  - Riva U
FAU - Lamberti, Filippo
AU  - Lamberti F
FAU - Carreras, Giovanni
AU  - Carreras G
FAU - Orazi, Serafino
AU  - Orazi S
FAU - Ribatti, Valentina
AU  - Ribatti V
FAU - Di Biase, Luigi
AU  - Di Biase L
FAU - Lovecchio, Mariolina
AU  - Lovecchio M
FAU - Natale, Andrea
AU  - Natale A
FAU - Valsecchi, Sergio
AU  - Valsecchi S
FAU - Romeo, Francesco
AU  - Romeo F
LA  - eng
PT  - Journal Article
DEP - 20150428
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of 
      arrhythmias and pacing
JID - 9708966
SB  - IM
MH  - Aged
MH  - *Defibrillators, Implantable
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Humans
MH  - Male
MH  - Monitoring, Physiologic/*instrumentation
MH  - Prospective Studies
MH  - Respiratory Rate/*physiology
MH  - Sensitivity and Specificity
EDAT- 2015/04/29 06:00
MHDA- 2016/11/01 06:00
CRDT- 2015/04/29 06:00
PHST- 2015/01/06 00:00 [received]
PHST- 2015/04/06 00:00 [accepted]
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - 10.1007/s10840-015-0007-3 [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2015 Aug;43(2):135-44. doi: 
      10.1007/s10840-015-0007-3. Epub 2015 Apr 28.