PMID- 25918450
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0142-2421 (Print)
IS  - 0142-2421 (Linking)
VI  - 46
IP  - Suppl 1
DP  - 2014 Nov
TI  - Analysis of liposome model systems by time-of-flight secondary ion mass 
      spectrometry.
PG  - 74-78
AB  - Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is an important 
      technique for studying chemical composition of micrometer scale objects due to 
      its high spatial resolution imaging capabilities and chemical specificity. In 
      this work we focus on the application of ToF-SIMS to gain insight into the 
      chemistry of micrometer size liposomes as a potential model for neurotransmitter 
      vesicles. Two models of giant liposomes were analyzed: histamine and aqueous two 
      phase system (ATPS)-containing liposomes. Characterization of the internal 
      structure of single fixed liposomes was done both with the Bi(3)(+) and C(60)(+) 
      ion sources. The depth profiling capability of ToF-SIMS was used to investigate 
      the liposome interior.
FAU - Lovric, Jelena
AU  - Lovric J
AD  - Department of Chemical and Biological Engineering, Chalmers University of 
      Technology, SE-412 96 Gothenburg, Sweden.
FAU - Keighron, Jacqueline D
AU  - Keighron JD
AD  - Department of Chemical and Biological Engineering, Chalmers University of 
      Technology, SE-412 96 Gothenburg, Sweden.
FAU - Angerer, Tina B
AU  - Angerer TB
AD  - Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 
      96 Gothenburg, Sweden.
FAU - Li, Xianchan
AU  - Li X
AD  - Department of Chemical and Biological Engineering, Chalmers University of 
      Technology, SE-412 96 Gothenburg, Sweden.
FAU - Malmberg, Per
AU  - Malmberg P
AD  - Department of Chemical and Biological Engineering, Chalmers University of 
      Technology, SE-412 96 Gothenburg, Sweden.
FAU - Fletcher, John S
AU  - Fletcher JS
AD  - Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 
      96 Gothenburg, Sweden.
FAU - Ewing, Andrew G
AU  - Ewing AG
AD  - Department of Chemical and Biological Engineering, Chalmers University of 
      Technology, SE-412 96 Gothenburg, Sweden ; Department of Chemistry and Molecular 
      Biology, University of Gothenburg, SE-412 96 Gothenburg, Sweden.
LA  - eng
GR  - R01 GM113746/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Surf Interface Anal
JT  - Surface and interface analysis : SIA
JID - 101479368
PMC - PMC4408321
MID - NIHMS677618
OTO - NOTNLM
OT  - ToF-SIMS
OT  - aqueous two phase system
OT  - depth profile analysis
OT  - histamine
OT  - imaging
OT  - liposome
EDAT- 2015/04/29 06:00
MHDA- 2015/04/29 06:01
PMCR- 2015/11/01
CRDT- 2015/04/29 06:00
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2015/04/29 06:01 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - 10.1002/sia.5623 [doi]
PST - ppublish
SO  - Surf Interface Anal. 2014 Nov;46(Suppl 1):74-78. doi: 10.1002/sia.5623.