PMID- 25918478
OWN - NLM
STAT- MEDLINE
DCOM- 20160201
LR  - 20181113
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2015
DP  - 2015
TI  - Evasion of early antiviral responses by herpes simplex viruses.
PG  - 593757
LID - 10.1155/2015/593757 [doi]
LID - 593757
AB  - Besides overcoming physical constraints, such as extreme temperatures, reduced 
      humidity, elevated pressure, and natural predators, human pathogens further need 
      to overcome an arsenal of antimicrobial components evolved by the host to limit 
      infection, replication and optimally, reinfection. Herpes simplex virus-1 (HSV-1) 
      and herpes simplex virus-2 (HSV-2) infect humans at a high frequency and persist 
      within the host for life by establishing latency in neurons. To gain access to 
      these cells, herpes simplex viruses (HSVs) must replicate and block immediate 
      host antiviral responses elicited by epithelial cells and innate immune 
      components early after infection. During these processes, infected and 
      noninfected neighboring cells, as well as tissue-resident and patrolling immune 
      cells, will sense viral components and cell-associated danger signals and secrete 
      soluble mediators. While type-I interferons aim at limiting virus spread, 
      cytokines and chemokines will modulate resident and incoming immune cells. In 
      this paper, we discuss recent findings relative to the early steps taking place 
      during HSV infection and replication. Further, we discuss how HSVs evade 
      detection by host cells and the molecular mechanisms evolved by these viruses to 
      circumvent early antiviral mechanisms, ultimately leading to neuron infection and 
      the establishment of latency.
FAU - Suazo, Paula A
AU  - Suazo PA
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, 8331010 Santiago, Chile.
FAU - Ibanez, Francisco J
AU  - Ibanez FJ
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, 8331010 Santiago, Chile.
FAU - Retamal-Diaz, Angello R
AU  - Retamal-Diaz AR
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, 8331010 Santiago, Chile.
FAU - Paz-Fiblas, Marysol V
AU  - Paz-Fiblas MV
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, 8331010 Santiago, Chile.
FAU - Bueno, Susan M
AU  - Bueno SM
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, 8331010 Santiago, Chile ; INSERM UMR1064, 44093 
      Nantes, France.
FAU - Kalergis, Alexis M
AU  - Kalergis AM
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, 8331010 Santiago, Chile ; INSERM UMR1064, 44093 
      Nantes, France ; Departamento de Inmunologia Clinica y Reumatologia, Escuela de 
      Medicina, Facultad de Medicina, Pontificia Universidad Catolica de Chile, 8331010 
      Santiago, Chile.
FAU - Gonzalez, Pablo A
AU  - Gonzalez PA
AD  - Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica 
      Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia 
      Universidad Catolica de Chile, 8331010 Santiago, Chile.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150330
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Antiviral Agents)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*chemistry
MH  - Apoptosis
MH  - Cell Survival
MH  - Chemokines/metabolism
MH  - Cytokines/metabolism
MH  - Epithelial Cells/virology
MH  - Herpes Simplex/immunology/*virology
MH  - Herpesvirus 1, Human/*metabolism
MH  - Humans
MH  - Immunity, Innate
MH  - Interferons/metabolism
MH  - Neurons/metabolism/virology
MH  - Signal Transduction
MH  - Virus Replication
PMC - PMC4396904
EDAT- 2015/04/29 06:00
MHDA- 2016/02/02 06:00
PMCR- 2015/03/30
CRDT- 2015/04/29 06:00
PHST- 2015/01/12 00:00 [received]
PHST- 2015/03/10 00:00 [accepted]
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2016/02/02 06:00 [medline]
PHST- 2015/03/30 00:00 [pmc-release]
AID - 10.1155/2015/593757 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2015;2015:593757. doi: 10.1155/2015/593757. Epub 2015 Mar 30.