PMID- 25918648
OWN - NLM
STAT- MEDLINE
DCOM- 20151104
LR  - 20181113
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2015
DP  - 2015
TI  - Neuronal BDNF signaling is necessary for the effects of treadmill exercise on 
      synaptic stripping of axotomized motoneurons.
PG  - 392591
LID - 10.1155/2015/392591 [doi]
LID - 392591
AB  - The withdrawal of synaptic inputs from the somata and proximal dendrites of 
      spinal motoneurons following peripheral nerve injury could contribute to poor 
      functional recovery. Decreased availability of neurotrophins to afferent 
      terminals on axotomized motoneurons has been implicated as one cause of the 
      withdrawal. No reduction in contacts made by synaptic inputs immunoreactive to 
      the vesicular glutamate transporter 1 and glutamic acid decarboxylase 67 is noted 
      on axotomized motoneurons if modest treadmill exercise, which stimulates the 
      production of neurotrophins by spinal motoneurons, is applied after nerve injury. 
      In conditional, neuron-specific brain-derived neurotrophic factor (BDNF) knockout 
      mice, a reduction in synaptic contacts onto motoneurons was noted in intact 
      animals which was similar in magnitude to that observed after nerve transection 
      in wild-type controls. No further reduction in coverage was found if nerves were 
      cut in knockout mice. Two weeks of moderate daily treadmill exercise following 
      nerve injury in these BDNF knockout mice did not affect synaptic inputs onto 
      motoneurons. Treadmill exercise has a profound effect on synaptic inputs to 
      motoneurons after peripheral nerve injury which requires BDNF production by those 
      postsynaptic cells.
FAU - Krakowiak, Joey
AU  - Krakowiak J
AD  - Department of Cell Biology, Emory University School of Medicine, 615 Michael 
      Street, Room 405P, Atlanta, GA 30322, USA.
FAU - Liu, Caiyue
AU  - Liu C
AD  - Department of Plastic and Reconstructive Surgery, Changzheng Hospital, Second 
      Military Medical University, Shanghai, China.
FAU - Papudesu, Chandana
AU  - Papudesu C
AD  - Department of Cell Biology, Emory University School of Medicine, 615 Michael 
      Street, Room 405P, Atlanta, GA 30322, USA.
FAU - Ward, P Jillian
AU  - Ward PJ
AD  - Department of Cell Biology, Emory University School of Medicine, 615 Michael 
      Street, Room 405P, Atlanta, GA 30322, USA.
FAU - Wilhelm, Jennifer C
AU  - Wilhelm JC
AD  - Department of Psychology, College of Charleston, 66 George Street, Charleston, SC 
      29424, USA.
FAU - English, Arthur W
AU  - English AW
AD  - Department of Cell Biology, Emory University School of Medicine, 615 Michael 
      Street, Room 405P, Atlanta, GA 30322, USA.
LA  - eng
GR  - HD032571/HD/NICHD NIH HHS/United States
GR  - P01 HD032571/HD/NICHD NIH HHS/United States
GR  - K12 GM000680/GM/NIGMS NIH HHS/United States
GR  - NS057190/NS/NINDS NIH HHS/United States
GR  - K12GM000680/GM/NIGMS NIH HHS/United States
GR  - R01 NS057190/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150331
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Axotomy
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Dendrites/physiology/ultrastructure
MH  - *Exercise Therapy
MH  - Female
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Neurons/metabolism/*physiology/ultrastructure
MH  - *Nerve Regeneration
MH  - Synapses/*physiology
PMC - PMC4397030
EDAT- 2015/04/29 06:00
MHDA- 2015/11/05 06:00
PMCR- 2015/03/31
CRDT- 2015/04/29 06:00
PHST- 2015/02/01 00:00 [received]
PHST- 2015/03/09 00:00 [revised]
PHST- 2015/03/16 00:00 [accepted]
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2015/11/05 06:00 [medline]
PHST- 2015/03/31 00:00 [pmc-release]
AID - 10.1155/2015/392591 [doi]
PST - ppublish
SO  - Neural Plast. 2015;2015:392591. doi: 10.1155/2015/392591. Epub 2015 Mar 31.