PMID- 25919383
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20220409
IS  - 1539-736X (Electronic)
IS  - 0022-3018 (Print)
IS  - 0022-3018 (Linking)
VI  - 203
IP  - 5
DP  - 2015 May
TI  - North American Prodrome Longitudinal Study (NAPLS 2): The Prodromal Symptoms.
PG  - 328-35
LID - 10.1097/NMD.0000000000000290 [doi]
AB  - In studies describing the long-term follow-up up of youth at clinical high risk 
      (CHR) of psychosis, little attention has been given to details of specific 
      prodromal symptoms. In this paper, we describe the prodromal symptoms of 764 CHR 
      participants recruited in the multi-site North American Prodrome Longitudinal 
      Study (NAPLS). Symptoms were rated on the Scale of Prodromal Symptoms (SOPS) at 
      baseline and 6-, 12-, 18-, and 24-month follow-ups. Clinical outcome at the 
      2-year assessment was categorized as psychotic, prodromal progression, 
      symptomatic or in remission. Most of the CHR sample (92%) met criteria for the 
      attenuated positive symptoms syndrome (APSS). Significant improvements in SOPS 
      symptoms were observed over time. Unusual thought content, disorganized 
      communication, and overall ratings on disorganized symptoms differentiated those 
      who transitioned to psychosis from the other clinical outcome groups. 
      Suspiciousness and total positive symptoms differentiated those in remission from 
      the other clinical outcome groups.
FAU - Addington, Jean
AU  - Addington J
AD  - *Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; 
      daggerDepartment of Psychiatry, UCSD, La Jolla, CA; double daggerDepartment of Psychology, Yale 
      University, New Haven, CT;  section signDepartment of Psychiatry, Zucker Hillside Hospital, 
      Long Island, NY;  parallelDepartment of Psychiatry, University of North Carolina, Chapel 
      Hill, NC;  paragraph signDepartment of Psychiatry, Harvard Medical School at Beth Israel 
      Deaconess Medical Center and Massachusetts General Hospital, Boston, MA; 
      #Departments of Psychology and Psychiatry, Emory University, Atlanta, GA; 
      **Department of Psychiatry, Yale University, New Haven, CT; daggerdaggerDepartments of 
      Psychiatry and Biobehavioral Sciences and Psychology, UCLA, Los Angeles; and 
      double daggerdouble daggerDepartment of Psychiatry, UCSF, and SFVA Medical Center, San Francisco, CA.
FAU - Liu, Lu
AU  - Liu L
FAU - Buchy, Lisa
AU  - Buchy L
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
FAU - Cannon, Tyrone D
AU  - Cannon TD
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
FAU - Perkins, Diana O
AU  - Perkins DO
FAU - Seidman, Larry J
AU  - Seidman LJ
FAU - Tsuang, Ming T
AU  - Tsuang MT
FAU - Walker, Elaine F
AU  - Walker EF
FAU - Woods, Scott W
AU  - Woods SW
FAU - Bearden, Carrie E
AU  - Bearden CE
FAU - Mathalon, Daniel H
AU  - Mathalon DH
FAU - McGlashan, Thomas H
AU  - McGlashan TH
LA  - eng
GR  - K24 MH76191/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - R01 MH60720/MH/NIMH NIH HHS/United States
GR  - U01MH082004/MH/NIMH NIH HHS/United States
GR  - P50MH066286/MH/NIMH NIH HHS/United States
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - U01MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - UO1MH081857-05/MH/NIMH NIH HHS/United States
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
GR  - U01MH081988/MH/NIMH NIH HHS/United States
GR  - U01 MH076989/MH/NIMH NIH HHS/United States
GR  - K24 MH076191/MH/NIMH NIH HHS/United States
GR  - U01MH081902/MH/NIMH NIH HHS/United States
GR  - U01MH081984/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH081944/MH/NIMH NIH HHS/United States
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nerv Ment Dis
JT  - The Journal of nervous and mental disease
JID - 0375402
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Algorithms
MH  - Case-Control Studies
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Disease Progression
MH  - *Early Diagnosis
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - North America
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Psychometrics
MH  - Psychotic Disorders/*diagnosis/genetics/*psychology
MH  - Remission, Spontaneous
MH  - Risk Assessment
MH  - Schizophrenia/*diagnosis/genetics
MH  - *Schizophrenic Psychology
MH  - Schizotypal Personality Disorder/*diagnosis/genetics/*psychology
MH  - Young Adult
PMC - PMC4417745
MID - NIHMS666668
EDAT- 2015/04/29 06:00
MHDA- 2015/06/30 06:00
PMCR- 2016/05/01
CRDT- 2015/04/29 06:00
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - 00005053-201505000-00005 [pii]
AID - 10.1097/NMD.0000000000000290 [doi]
PST - ppublish
SO  - J Nerv Ment Dis. 2015 May;203(5):328-35. doi: 10.1097/NMD.0000000000000290.