PMID- 25919384
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20181202
IS  - 1539-736X (Electronic)
IS  - 0022-3018 (Linking)
VI  - 203
IP  - 5
DP  - 2015 May
TI  - Evidence-based early interventions for individuals at clinical high risk for 
      psychosis: a review of treatment components.
PG  - 342-51
LID - 10.1097/NMD.0000000000000287 [doi]
AB  - Youth and young adults at clinical high risk (CHR) for psychosis experience a 
      broad range of difficulties, including attenuated psychotic symptoms, comorbid 
      concerns, functional impairments, and family and interpersonal stress. Given 
      emerging evidence that early interventions may improve functioning and reduce 
      symptomatology while also lowering risk of transition to full-threshold 
      psychosis, several randomized controlled trials have systematically evaluated the 
      efficacy of CHR treatment approaches. This article describes and summarizes 
      psychosocial intervention approaches that have demonstrated efficacy in treating 
      people at CHR, with a focus on distilling individual components of these 
      treatments. On the basis of the existing literature, we propose an empirically 
      based, flexible, and comprehensive modularized approach to early intervention 
      that meets the varying needs of individuals experiencing CHR-related distress and 
      dysfunction, many of whom may be on a trajectory toward psychosis.
FAU - Thompson, Elizabeth
AU  - Thompson E
AD  - *Department of Psychology, University of Maryland, Baltimore County; daggerDivision of 
      Child and Adolescent Psychiatry, University of Maryland, Baltimore; double daggerDepartment 
      of Psychology and Neuroscience, University of Colorado at Boulder; and  section signSchool of 
      Social Work and  parallelMaryland Psychiatric Research Center, School of Medicine, 
      University of Maryland, Baltimore.
FAU - Millman, Zachary B
AU  - Millman ZB
FAU - Okuzawa, Nana
AU  - Okuzawa N
FAU - Mittal, Vijay
AU  - Mittal V
FAU - DeVylder, Jordan
AU  - DeVylder J
FAU - Skadberg, Travis
AU  - Skadberg T
FAU - Buchanan, Robert W
AU  - Buchanan RW
FAU - Reeves, Gloria M
AU  - Reeves GM
FAU - Schiffman, Jason
AU  - Schiffman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Nerv Ment Dis
JT  - The Journal of nervous and mental disease
JID - 0375402
SB  - IM
MH  - Adolescent
MH  - Caregivers/education
MH  - Cognitive Behavioral Therapy
MH  - Combined Modality Therapy
MH  - Disease Progression
MH  - *Early Medical Intervention
MH  - *Evidence-Based Medicine
MH  - Family Therapy
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Patient Care Planning
MH  - *Prodromal Symptoms
MH  - Psychotherapy, Group
MH  - Psychotic Disorders/genetics/psychology/*therapy
MH  - Randomized Controlled Trials as Topic
MH  - Social Adjustment
MH  - Young Adult
EDAT- 2015/04/29 06:00
MHDA- 2015/06/30 06:00
CRDT- 2015/04/29 06:00
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
AID - 00005053-201505000-00007 [pii]
AID - 10.1097/NMD.0000000000000287 [doi]
PST - ppublish
SO  - J Nerv Ment Dis. 2015 May;203(5):342-51. doi: 10.1097/NMD.0000000000000287.