PMID- 25920015
OWN - NLM
STAT- MEDLINE
DCOM- 20180227
LR  - 20181202
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 38 Suppl 1
DP  - 2016 Apr
TI  - Predictors of mucositis in oropharyngeal and oral cavity cancer in patients 
      treated with volumetric modulated radiation treatment: A dose-volume analysis.
PG  - E815-9
LID - 10.1002/hed.24106 [doi]
AB  - BACKGROUND: The purpose of this study was to assess predictors of mucositis in 
      oropharyngeal and oral cavity cancer after definitive or adjuvant volumetric 
      modulated arc radiotherapy (VMAT) +/- chemotherapy. METHODS: Fifty patients were 
      evaluated. Statistical analysis was performed for the following parameters as 
      potential predictors of mucositis >/= G2: total oral mucosa and oral mucosa minus 
      target high-low radiation dose regions (planning target volumes [PTVs]), mean 
      dose (Dmean ), maximum dose (Dmax ), chemotherapy, weight loss, and dysphagia. 
      RESULTS: Mucositis >/= G2 was found to be statistically related to chemotherapy, 
      weight loss, dysphagia >/= G2, total oral mucosa Dmean >/=50 Gy and Dmax >/=65 Gy, V45 
      Gy >40%, V50 Gy >30%, and V55 Gy >20% of the oral mucosa minus target PTVs. A 
      ratio between total oral mucosa and oral mucosa minus target PTVs >2.5 is related 
      to G3 mucositis (p = .03). CONCLUSION: New parameters were found as predictors of 
      moderate-severe mucositis. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: 
      E815-E819, 2016.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Mazzola, Rosario
AU  - Mazzola R
AD  - Department of Radiation Oncology, Sacro Cuore Don Calabria Hospital, 
      Negrar-Verona, Italy.
AD  - Department of Radiation Oncology School, University of Palermo, Palermo, Italy.
FAU - Ricchetti, Francesco
AU  - Ricchetti F
AD  - Department of Radiation Oncology, Sacro Cuore Don Calabria Hospital, 
      Negrar-Verona, Italy.
FAU - Fersino, Sergio
AU  - Fersino S
AD  - Department of Radiation Oncology, Sacro Cuore Don Calabria Hospital, 
      Negrar-Verona, Italy.
FAU - Fiorentino, Alba
AU  - Fiorentino A
AD  - Department of Radiation Oncology, Sacro Cuore Don Calabria Hospital, 
      Negrar-Verona, Italy.
FAU - Giaj Levra, Niccolo
AU  - Giaj Levra N
AD  - Department of Radiation Oncology, Sacro Cuore Don Calabria Hospital, 
      Negrar-Verona, Italy.
FAU - Di Paola, Gioacchino
AU  - Di Paola G
AD  - Statistic Sciences Faculty, University of Palermo, Palermo, Italy.
FAU - Ruggieri, Ruggero
AU  - Ruggieri R
AD  - Department of Radiation Oncology, Sacro Cuore Don Calabria Hospital, 
      Negrar-Verona, Italy.
FAU - Alongi, Filippo
AU  - Alongi F
AD  - Department of Radiation Oncology, Sacro Cuore Don Calabria Hospital, 
      Negrar-Verona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150715
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*pathology/radiotherapy
MH  - Mucositis/*diagnosis/pathology
MH  - Oropharyngeal Neoplasms/*pathology/radiotherapy
MH  - Radiotherapy Planning, Computer-Assisted
MH  - *Radiotherapy, Intensity-Modulated
OTO - NOTNLM
OT  - head neck cancer
OT  - mucositis
OT  - organ sparing
OT  - volumetric modulated arc radiotherapy (VMAT)
EDAT- 2015/04/29 06:00
MHDA- 2018/02/28 06:00
CRDT- 2015/04/29 06:00
PHST- 2015/04/16 00:00 [accepted]
PHST- 2015/04/29 06:00 [entrez]
PHST- 2015/04/29 06:00 [pubmed]
PHST- 2018/02/28 06:00 [medline]
AID - 10.1002/hed.24106 [doi]
PST - ppublish
SO  - Head Neck. 2016 Apr;38 Suppl 1:E815-9. doi: 10.1002/hed.24106. Epub 2015 Jul 15.