PMID- 25920591
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20181113
IS  - 1867-0687 (Electronic)
VI  - 11
IP  - 2
DP  - 2015 May
TI  - Prognostic significance of cytokine receptor-like factor 2 alterations in acute 
      lymphoblastic leukemia: a meta-analysis.
PG  - 126-33
LID - 10.1007/s12519-015-0019-1 [doi]
AB  - BACKGROUND: Cytokine receptor-like factor 2 (CRLF2) has been shown to play a role 
      in the pathogenesis of acute lymphoblastic leukemia (ALL). Studies have examined 
      the relationship between CRLF2 alterations such as over-expression or 
      deregulation and clinical outcome in childhood ALL, but the results are 
      conflicting. This meta-analysis aimed to explore the association between CRLF2 
      alterations and survival of pediatric patients with ALL. METHODS: Electronic 
      databases updated to March 2014 were searched for relevant studies. A 
      meta-analysis was made of twelve studies including 5945 patients to evaluate the 
      prognostic significance of CRLF2 alterations on survival in childhood ALL. 
      Hazards ratios (HRs) with 95% confidence intervals (CIs) were pooled across the 
      studies using a fixed-effects model. RESULTS: CRLF2 over-expression in childhood 
      ALL was associated with poor prognosis in terms of relapse-free survival (RFS; 
      HR=1.70, 95% CI=1.28-2.24, P=0.000), event-free survival (EFS; HR=1.78, 95% 
      CI=1.05-3.01, P=0.032), and overall survival (OS; HR=2.28, 95% CI=1.42-3.65, 
      P=0.001). The combined data also suggested that CRLF2 deregulation in childhood 
      ALL was correlated with poor EFS (HR=1.95, 95% CI=1.46-2.61, P=0.000), RFS 
      (HR=2.20, 95% CI=1.53-3.18, P=0.000), and OS (HR=1.89, 95% CI=1.24-2.87, 
      P=0.003). Subgroup analysis on multivariate HRs showed that CRLF2 deregulation 
      independently predicted a poor prognosis for childhood ALL. CONCLUSIONS: The 
      present meta-analysis reveals that both CRLF2 over-expression and deregulation 
      are associated with poor prognosis in pediatric patients with ALL.
FAU - Jia, Ming
AU  - Jia M
AD  - Division of Hematology-oncology, Children's Hospital, Zhejiang University School 
      of Medicine, Key Laboratory of Reproductive Genetics (Zhejiang University), 
      Ministry of Education, Hangzhou, 310003, China.
FAU - Wang, Zhu-Jun
AU  - Wang ZJ
FAU - Zhao, Hai-Zhao
AU  - Zhao HZ
FAU - Shen, He-Ping
AU  - Shen HP
FAU - Cheng, Yu-Ping
AU  - Cheng YP
FAU - Luo, Ze-Bin
AU  - Luo ZB
FAU - Tang, Yong-Min
AU  - Tang YM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150430
PL  - Switzerland
TA  - World J Pediatr
JT  - World journal of pediatrics : WJP
JID - 101278599
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CRLF2 protein, human)
RN  - 0 (Receptors, Cytokine)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Child
MH  - Humans
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology/*genetics
MH  - Prognosis
MH  - Receptors, Cytokine/*genetics
MH  - Survival Analysis
EDAT- 2015/04/30 06:00
MHDA- 2016/01/26 06:00
CRDT- 2015/04/30 06:00
PHST- 2013/10/02 00:00 [received]
PHST- 2014/08/26 00:00 [accepted]
PHST- 2015/04/30 06:00 [entrez]
PHST- 2015/04/30 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
AID - 10.1007/s12519-015-0019-1 [doi]
PST - ppublish
SO  - World J Pediatr. 2015 May;11(2):126-33. doi: 10.1007/s12519-015-0019-1. Epub 2015 
      Apr 30.