PMID- 25920668
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20190108
IS  - 1365-2540 (Electronic)
IS  - 0018-067X (Print)
IS  - 0018-067X (Linking)
VI  - 115
IP  - 5
DP  - 2015 Nov
TI  - Genome-wide QTL mapping of saltwater tolerance in sibling species of Anopheles 
      (malaria vector) mosquitoes.
PG  - 471-9
LID - 10.1038/hdy.2015.39 [doi]
AB  - Although freshwater (FW) is the ancestral habitat for larval mosquitoes, multiple 
      species independently evolved the ability to survive in saltwater (SW). Here, we 
      use quantitative trait locus (QTL) mapping to investigate the genetic 
      architecture of osmoregulation in Anopheles mosquitoes, vectors of human malaria. 
      We analyzed 1134 backcross progeny from a cross between the obligate FW species 
      An. coluzzii, and its closely related euryhaline sibling species An. merus. Tests 
      of 2387 markers with Bayesian interval mapping and machine learning (random 
      forests) yielded six genomic regions associated with SW tolerance. Overlap in QTL 
      regions from both approaches enhances confidence in QTL identification. Evidence 
      exists for synergistic as well as disruptive epistasis among loci. Intriguingly, 
      one QTL region containing ion transporters spans the 2Rop chromosomal inversion 
      that distinguishes these species. Rather than a simple trait controlled by one or 
      a few loci, our data are most consistent with a complex, polygenic mode of 
      inheritance.
FAU - Smith, H A
AU  - Smith HA
AD  - Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
AD  - Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
FAU - White, B J
AU  - White BJ
AD  - Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
AD  - Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
AD  - Department of Entomology, University of California-Riverside, Riverside, CA, USA.
FAU - Kundert, P
AU  - Kundert P
AD  - Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
AD  - Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
FAU - Cheng, C
AU  - Cheng C
AD  - Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
AD  - Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
FAU - Romero-Severson, J
AU  - Romero-Severson J
AD  - Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
AD  - Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
FAU - Andolfatto, P
AU  - Andolfatto P
AD  - Department of Ecology and Evolutionary Biology, Princeton University, Princeton, 
      NJ, USA.
AD  - The Lewis-Sigler Institute for Integrative Genomics, Princeton University, 
      Princeton, NJ, USA.
FAU - Besansky, N J
AU  - Besansky NJ
AD  - Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
AD  - Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
LA  - eng
SI  - SRA/SRP050537
GR  - R21 AI101459/AI/NIAID NIH HHS/United States
GR  - 1R21AI101459/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150429
PL  - England
TA  - Heredity (Edinb)
JT  - Heredity
JID - 0373007
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Animals
MH  - Anopheles/classification/*genetics
MH  - Bayes Theorem
MH  - Chromosome Inversion
MH  - *Chromosome Mapping
MH  - Crosses, Genetic
MH  - Female
MH  - Genetic Markers
MH  - Genotype
MH  - Insect Vectors/classification/genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - *Quantitative Trait Loci
MH  - Salt Tolerance
MH  - Seawater
MH  - Sequence Analysis, DNA
PMC - PMC4611235
EDAT- 2015/04/30 06:00
MHDA- 2016/04/15 06:00
PMCR- 2016/11/01
CRDT- 2015/04/30 06:00
PHST- 2014/11/30 00:00 [received]
PHST- 2015/03/11 00:00 [revised]
PHST- 2015/03/20 00:00 [accepted]
PHST- 2015/04/30 06:00 [entrez]
PHST- 2015/04/30 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
PHST- 2016/11/01 00:00 [pmc-release]
AID - hdy201539 [pii]
AID - 10.1038/hdy.2015.39 [doi]
PST - ppublish
SO  - Heredity (Edinb). 2015 Nov;115(5):471-9. doi: 10.1038/hdy.2015.39. Epub 2015 Apr 
      29.