PMID- 25921520
OWN - NLM
STAT- MEDLINE
DCOM- 20160212
LR  - 20161125
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 218
IP  - 5
DP  - 2015 Jul
TI  - Association between perfluoroalkyl substances and reproductive hormones in 
      adolescents and young adults.
PG  - 437-43
LID - S1438-4639(15)00041-3 [pii]
LID - 10.1016/j.ijheh.2015.03.008 [doi]
AB  - BACKGROUND: Few studies have explored the association between perfluoroalkyl 
      substances (PFAS) and reproductive hormones in adolescents and young adults. 
      OBJECTIVES: This study aimed to investigate the association of PFAS with 
      reproductive hormones in adolescents and young adults. METHODS: We recruited 540 
      subjects aged 12-30 years from a 1992 to 2000 mass urine screening population and 
      established a cohort from 2006 to 2008 via invitations by mail or/and telephone. 
      Serum PFAS levels were analyzed with a Waters ACQUITY UPLC system coupled with a 
      Waters Quattro Premier XE triple quadrupole mass spectrometer. Serum reproductive 
      hormone levels were measured by immunoluminometric assay with an Architect random 
      access assay system. PFAS levels were divided into different percentiles 
      according to their detection limits in the multiple regression models to analyze 
      associations between reproductive hormone levels and exposure with PFAS. RESULTS: 
      The adjusted mean serum level of sex hormone-binding globulin (SHBG) decreased 
      significantly in association with the <50th, 50-75, 75-90 and >90th percentile 
      categories of perfluorooctanoic acid (PFOA) compared with a reference category 
      for the females in the 12-17-year-old group. The follicle-stimulating hormone 
      (FSH) levels were significantly decreased in association with the different 
      percentile categories of perfluorooctane sulfonate (PFOS) in the male 
      12-17-year-old group and the different percentile categories of 
      perfluoroundecanoic acid (PFUA) in the female 12-17-year-old group. The serum FSH 
      levels in the females aged 12-17 were also decreased in association with the 
      different percentile categories of PFUA. On the other hand, there was a 
      significantly negative association between the different percentile categories of 
      PFOS and the serum testosterone level among the female 12-17-year-old group. 
      CONCLUSIONS: We found that the serum concentrations of PFOA, PFOS, and PFUA were 
      negatively associated with the serum levels of SHBG, FSH, and testosterone in the 
      young Taiwanese population and that these effects were the strongest in the 
      females aged 12-17. Further studies are needed to determine whether these 
      associations are causal.
CI  - Copyright (c) 2015 Elsevier GmbH. All rights reserved.
FAU - Tsai, Meng-Shan
AU  - Tsai MS
AD  - Institute of Occupational Medicine and Industrial Hygiene, College of Public 
      Health, National Taiwan University, Taipei 100, Taiwan.
FAU - Lin, Chien-Yu
AU  - Lin CY
AD  - Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, 
      Taiwan; School of Medicine, Fu Jen Catholic University, Taipei County 242, 
      Taiwan.
FAU - Lin, Ching-Chun
AU  - Lin CC
AD  - Institute of Occupational Medicine and Industrial Hygiene, College of Public 
      Health, National Taiwan University, Taipei 100, Taiwan.
FAU - Chen, Mei-Huei
AU  - Chen MH
AD  - Department of Pediatrics, National Taiwan University Hospital Yun-Lin Branch, 
      Yunlin County 640, Taiwan.
FAU - Hsu, Sandy H J
AU  - Hsu SH
AD  - Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Chien, Kuo-Liong
AU  - Chien KL
AD  - Institute of Epidemiology and Preventive Medicine, College of Public Health, 
      National Taiwan University, Taipei 100, Taiwan; Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100, Taiwan.
FAU - Sung, Fung-Chang
AU  - Sung FC
AD  - Department of Public Health, College of Public Health, China Medical University, 
      Taichung 404, Taiwan.
FAU - Chen, Pau-Chung
AU  - Chen PC
AD  - Institute of Occupational Medicine and Industrial Hygiene, College of Public 
      Health, National Taiwan University, Taipei 100, Taiwan; Department of Public 
      Health, National Taiwan University College of Public Health, Taipei 100, Taiwan; 
      Department of Environmental and Occupational Medicine, National Taiwan University 
      Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan. 
      Electronic address: pchen@ntu.edu.tw.
FAU - Su, Ta-Chen
AU  - Su TC
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, 
      Taiwan; Department of Environmental and Occupational Medicine, National Taiwan 
      University Hospital and National Taiwan University College of Medicine, Taipei 
      100, Taiwan. Electronic address: tachensu@ntu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150326
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Hormones)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 0 (perfluoroundecanoic acid)
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alkanesulfonic Acids/*adverse effects
MH  - Caprylates/*adverse effects
MH  - Child
MH  - Cohort Studies
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*adverse effects
MH  - Fatty Acids/*adverse effects
MH  - Female
MH  - Fluorocarbons/*adverse effects
MH  - Follicle Stimulating Hormone/blood
MH  - Hormones/*blood
MH  - Humans
MH  - Male
MH  - Reproduction/*drug effects
MH  - Sex Hormone-Binding Globulin/metabolism
MH  - Testosterone/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Adolescent
OT  - Perfluoroalkyl substances
OT  - Reproductive hormone
OT  - Young adults
EDAT- 2015/04/30 06:00
MHDA- 2016/02/13 06:00
CRDT- 2015/04/30 06:00
PHST- 2014/11/12 00:00 [received]
PHST- 2015/03/16 00:00 [revised]
PHST- 2015/03/17 00:00 [accepted]
PHST- 2015/04/30 06:00 [entrez]
PHST- 2015/04/30 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
AID - S1438-4639(15)00041-3 [pii]
AID - 10.1016/j.ijheh.2015.03.008 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2015 Jul;218(5):437-43. doi: 
      10.1016/j.ijheh.2015.03.008. Epub 2015 Mar 26.