PMID- 25922420
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20181113
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Print)
IS  - 0269-8811 (Linking)
VI  - 29
IP  - 6
DP  - 2015 Jun
TI  - Intimate insight: MDMA changes how people talk about significant others.
PG  - 669-77
LID - 10.1177/0269881115581962 [doi]
AB  - RATIONALE: +/-3,4-methylenedioxymethamphetamine (MDMA) is widely believed to 
      increase sociability. The drug alters speech production and fluency, and may 
      influence speech content. Here, we investigated the effect of MDMA on speech 
      content, which may reveal how this drug affects social interactions. METHOD: 
      Thirty-five healthy volunteers with prior MDMA experience completed this 
      two-session, within-subjects, double-blind study during which they received 1.5 
      mg/kg oral MDMA and placebo. Participants completed a five-minute standardized 
      talking task during which they discussed a close personal relationship (e.g. a 
      friend or family member) with a research assistant. The conversations were 
      analyzed for selected content categories (e.g. words pertaining to affect, social 
      interaction, and cognition), using both a standard dictionary method 
      (Pennebaker's Linguistic Inquiry and Word Count: LIWC) and a machine learning 
      method using random forest classifiers. RESULTS: Both analytic methods revealed 
      that MDMA altered speech content relative to placebo. Using LIWC scores, the drug 
      increased use of social and sexual words, consistent with reports that MDMA 
      increases willingness to disclose. Using the machine learning algorithm, we found 
      that MDMA increased use of social words and words relating to both positive and 
      negative emotions. CONCLUSIONS: These findings are consistent with reports that 
      MDMA acutely alters speech content, specifically increasing emotional and social 
      content during a brief semistructured dyadic interaction. Studying effects of 
      psychoactive drugs on speech content may offer new insights into drug effects on 
      mental states, and on emotional and psychosocial interaction.
CI  - (c) The Author(s) 2015.
FAU - Baggott, Matthew J
AU  - Baggott MJ
AD  - Department of Psychiatry and Behavioral Neurosciences, University of Chicago, 
      Chicago, IL, USA.
FAU - Kirkpatrick, Matthew G
AU  - Kirkpatrick MG
AD  - Department of Preventive Medicine, University of Southern California, Los 
      Angeles, CA, USA.
FAU - Bedi, Gillinder
AU  - Bedi G
AD  - Department of Psychiatry, Columbia University, New York, NY, USA.
FAU - de Wit, Harriet
AU  - de Wit H
AD  - Department of Psychiatry and Behavioral Neurosciences, University of Chicago, 
      Chicago, IL, USA hdew@uchicago.edu.
LA  - eng
GR  - UL1 TR000430/TR/NCATS NIH HHS/United States
GR  - R01 DA02812/DA/NIDA NIH HHS/United States
GR  - R21 DA026570/DA/NIDA NIH HHS/United States
GR  - K23 DA034877/DA/NIDA NIH HHS/United States
GR  - R01 DA002812/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20150428
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Hallucinogens)
RN  - 0 (Psychotropic Drugs)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Cognition/drug effects
MH  - Double-Blind Method
MH  - Emotions/drug effects
MH  - Empathy/drug effects
MH  - Female
MH  - Hallucinogens/*pharmacology
MH  - Healthy Volunteers
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Psychotropic Drugs/*pharmacology
MH  - Social Behavior
MH  - Speech/*drug effects
MH  - Young Adult
PMC - PMC4698152
MID - NIHMS745244
OTO - NOTNLM
OT  - 4-Methylenedioxymethamphetamine
OT  - ecstasy
OT  - emotion
OT  - entactogen
OT  - speech
OT  - +/-3
EDAT- 2015/04/30 06:00
MHDA- 2016/02/24 06:00
PMCR- 2016/06/01
CRDT- 2015/04/30 06:00
PHST- 2015/04/30 06:00 [entrez]
PHST- 2015/04/30 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - 0269881115581962 [pii]
AID - 10.1177/0269881115581962 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2015 Jun;29(6):669-77. doi: 10.1177/0269881115581962. Epub 
      2015 Apr 28.