PMID- 25923415
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150430
LR  - 20240323
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 5
IP  - 2
DP  - 2015 Apr 27
TI  - Mathematical modelling of metabolic regulation in aging.
PG  - 232-51
LID - 10.3390/metabo5020232 [doi]
AB  - The underlying cellular mechanisms that characterize aging are complex and 
      multifaceted. However, it is emerging that aging could be regulated by two 
      distinct metabolic hubs. These hubs are the pathway defined by the mammalian 
      target of rapamycin (mTOR) and that defined by the NAD+-dependent deacetylase 
      enzyme, SIRT1. Recent experimental evidence suggests that there is crosstalk 
      between these two important pathways; however, the mechanisms underpinning their 
      interaction(s) remains poorly understood. In this review, we propose using 
      computational modelling in tandem with experimentation to delineate the 
      mechanism(s). We briefly discuss the main modelling frameworks that could be used 
      to disentangle this relationship and present a reduced reaction pathway that 
      could be modelled. We conclude by outlining the limitations of computational 
      modelling and by discussing opportunities for future progress in this area.
FAU - Auley, Mark T Mc
AU  - Auley MT
AD  - Faculty of Science & Engineering, University of Chester, Thornton Science Park, 
      CH2 4NU, UK. m.mcauley@chester.ac.uk.
FAU - Mooney, Kathleen M
AU  - Mooney KM
AD  - Faculty of Health and Social Care, Edge Hill University, Ormskirk, Lancashire, 
      L39 4QP, UK. kathleen.mooney@edgehill.ac.uk.
FAU - Angell, Peter J
AU  - Angell PJ
AD  - School of Health Sciences, Liverpool Hope University, Taggart Avenue, Liverpool, 
      L16 9JD, UK. angellp@hope.ac.uk.
FAU - Wilkinson, Stephen J
AU  - Wilkinson SJ
AD  - Faculty of Science & Engineering, University of Chester, Thornton Science Park, 
      CH2 4NU, UK. s.j.wilkinson@chester.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150427
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC4495371
EDAT- 2015/04/30 06:00
MHDA- 2015/04/30 06:01
PMCR- 2015/06/01
CRDT- 2015/04/30 06:00
PHST- 2014/11/03 00:00 [received]
PHST- 2015/03/24 00:00 [revised]
PHST- 2015/03/25 00:00 [accepted]
PHST- 2015/04/30 06:00 [entrez]
PHST- 2015/04/30 06:00 [pubmed]
PHST- 2015/04/30 06:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - metabo5020232 [pii]
AID - metabolites-05-00232 [pii]
AID - 10.3390/metabo5020232 [doi]
PST - epublish
SO  - Metabolites. 2015 Apr 27;5(2):232-51. doi: 10.3390/metabo5020232.