PMID- 25923834
OWN - NLM
STAT- MEDLINE
DCOM- 20160224
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Apr 29
TI  - Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer.
PG  - 9613
LID - 10.1038/srep09613 [doi]
LID - 9613
AB  - Dendritic cells (DCs) play important roles in the initiation and maintenance of 
      the immune response. The dysfunction of DCs contributes to tumor evasion and 
      growth. Here we report our findings on the dysfunction of DCs in 
      radiation-induced thymic lymphomas, and the up-regulation of the expression of 
      the lipoprotein lipase (LPL) and the fatty acid binding protein (FABP4), and the 
      level of triacylglycerol (TAG) in serum after total body irradiation, which 
      contribute to DCs lipid accumulation. DCs with high lipid content showed low 
      expression of co-stimulatory molecules and DCs-related cytokines, and were not 
      able to effectively stimulate allogeneic T cells. Normalization of lipid 
      abundance in DCs with an inhibitor of acetyl-CoA carboxylase restored the 
      function of DCs. A high-fat diet promoted radiation-induced thymic lymphoma 
      growth. In all, our study shows that dysfunction of DCs in radiation-induced 
      thymic lymphomas was due to lipid accumulation and may represent a new mechanism 
      in radiation-induced carcinogenesis.
FAU - Gao, Fu
AU  - Gao F
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Liu, Cong
AU  - Liu C
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Guo, Jiaming
AU  - Guo J
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Sun, Weimin
AU  - Sun W
AD  - National Key Laboratory of Medical Immunology &Institute of Immunology, Second 
      Military Medical University, Shanghai 200433, China.
FAU - Xian, Linfeng
AU  - Xian L
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Bai, Dongchen
AU  - Bai D
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Liu, Hu
AU  - Liu H
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Cheng, Ying
AU  - Cheng Y
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Li, Bailong
AU  - Li B
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Cui, Jianguo
AU  - Cui J
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
FAU - Zhang, Chaoxiong
AU  - Zhang C
AD  - Department of Centre for Disease Prevention and Control, Chengdu Military Region, 
      Chengdu610021, China.
FAU - Cai, Jianming
AU  - Cai J
AD  - Department of Radiation Medicine, Faculty of Naval Medicine, Second Military 
      Medical University, Shanghai 200433, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150429
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Cytokines)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Triglycerides)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
RN  - EC 6.4.1.2 (Acetyl-CoA Carboxylase)
SB  - IM
MH  - Acetyl-CoA Carboxylase/metabolism
MH  - Animals
MH  - Carcinogenesis/radiation effects
MH  - Cytokines/metabolism
MH  - Dendritic Cells/metabolism/pathology/*radiation effects
MH  - Diet, High-Fat/adverse effects
MH  - Fatty Acid-Binding Proteins/metabolism
MH  - Gamma Rays/*adverse effects
MH  - Lipid Metabolism/*radiation effects
MH  - Lipoprotein Lipase/metabolism
MH  - Lymphoma/blood/metabolism/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - T-Lymphocytes/metabolism/pathology/radiation effects
MH  - Thymus Neoplasms/blood/metabolism/*pathology
MH  - Triglycerides/blood
MH  - Up-Regulation/radiation effects
PMC - PMC4413852
EDAT- 2015/04/30 06:00
MHDA- 2016/02/26 06:00
PMCR- 2015/04/29
CRDT- 2015/04/30 06:00
PHST- 2014/10/23 00:00 [received]
PHST- 2015/03/09 00:00 [accepted]
PHST- 2015/04/30 06:00 [entrez]
PHST- 2015/04/30 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PHST- 2015/04/29 00:00 [pmc-release]
AID - srep09613 [pii]
AID - 10.1038/srep09613 [doi]
PST - epublish
SO  - Sci Rep. 2015 Apr 29;5:9613. doi: 10.1038/srep09613.