PMID- 25924473
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20181202
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 50
IP  - 1
DP  - 2015 Jan
TI  - [Effect of allitridum on remodeling of the transient outward potassium current of 
      ventricular myocytes of spontaneously hypertensive rats].
PG  - 39-44
AB  - We aimed to study the effect of allitridum (All) on the transient outward 
      potassium current (Ito) of ventricular myocytes of spontaneously hypertensive 
      rats (SHR). Totally 30 male SHRs were randomly divided into three groups: 
      low-dose All group (7.5 mg.kg(-1)), high-dose All group (15.0 mg.kg(-1)) and 
      normal saline group. The other 10 sex and age matched Wistar-kyoto rats (WKY) 
      were also taken as control group (WKY group). All animals received i.p. 
      administration for 8 weeks. The dual enzymatic method was used to separate single 
      ventricular myocyte from animals. Patch-clamp technique was used to record Ito 
      and analyze the effect of All on the current. It was shown that the left 
      ventricular hypertrophy of SHR was reversed significantly by All. Furthermore, 
      the density of Ito was recovered in both high and low dose All groups. The peak 
      current densities of Ito were enhanced from 18.23+/-3.64 to 25.17+/-2.86 pA/pF 
      (P<0.01) and 36.47+/-5.42 pA/pF (P<0.01) at +50 mV by All 7.5 mg.kg(-1) and 15.0 
      mg.kg(-1), respectively, which was not significantly different with WKY group. 
      The effect was associated with positive shift of the steady-state, close-state 
      inactivation, and shortened recovery from inactivation of Ito. It is concluded 
      that All decreases the remodeling of Ito of ventricular hypertrophic myocytes of 
      SHR.
FAU - Dan, Qing
AU  - Dan Q
FAU - Zhao, Ying
AU  - Zhao Y
FAU - Wu, Zhi-juan
AU  - Wu ZJ
FAU - Zhu, Chao
AU  - Zhu C
FAU - Liu, Li
AU  - Liu L
FAU - Xu, Bin
AU  - Xu B
FAU - Liu, Yu-qi
AU  - Liu YQ
FAU - Chen, Qi
AU  - Chen Q
FAU - Li, Yang
AU  - Li Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Allyl Compounds)
RN  - 0 (Potassium Channels)
RN  - 0 (Sulfides)
RN  - 0ZO1U5A3XX (diallyl trisulfide)
SB  - IM
MH  - Allyl Compounds/*pharmacology
MH  - Animals
MH  - Hypertrophy, Left Ventricular/*drug therapy
MH  - Male
MH  - Myocytes, Cardiac/cytology/*drug effects
MH  - Patch-Clamp Techniques
MH  - Potassium Channels/*metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Sulfides/*pharmacology
EDAT- 2015/05/01 06:00
MHDA- 2015/07/15 06:00
CRDT- 2015/05/01 06:00
PHST- 2015/05/01 06:00 [entrez]
PHST- 2015/05/01 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2015 Jan;50(1):39-44.