PMID- 25924480
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20181202
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 50
IP  - 1
DP  - 2015 Jan
TI  - [Determination of 10 mycotoxin contaminants in Panax notoginseng by ultra 
      performance liquid chromatography-tandem mass spectrometry].
PG  - 81-5
AB  - To ensure the quality and safety of Panax notoginseng, a method for the 
      simultaneous determination of 10 mycotoxins in Panax notoginseng was developed 
      using ultra performance liquid chromatography tandem mass spectrometry 
      (UPLC-MS/MS). The sample was extracted with acetonitrile and purified by HLB 
      multifunction cleanup column. The separation was performed on a Phenomenex 
      Kinetex XB-C18 column by gradient elution using methanol and 5 mmol.L(-1) 
      ammonium acetate as mobile phase. The targeted compounds were detected in MRM 
      mode by mass spectrometry with electrospray ionization (ESI) source operated in 
      both positive and negative ionization modes. The linear relationships of the 10 
      mycotoxins were good in their respective linear ranges. The correlation 
      coefficients (r) ranged from 0.9981 to 1.0000. The LOQs of the 10 mycotoxins were 
      between 0.15 and 8.6 mug.kg(-1). The average recoveries ranged from 73.8% to 
      107.0% with relative standard deviations (RSDs) of 0.10%-10.9%. The results 
      demonstrated that the proposed method was sensitive and accurate, and suitable 
      for the mycotoxins quantification in Panax notoginseng.
FAU - Chen, Yong
AU  - Chen Y
FAU - Chen, Chong-jun
AU  - Chen CJ
FAU - Li, Jin
AU  - Li J
FAU - Luan, Lian-jun
AU  - Luan LJ
FAU - Liu, Xue-song
AU  - Liu XS
FAU - Wu, Yong-jiang
AU  - Wu YJ
LA  - chi
PT  - Journal Article
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Mycotoxins)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Chromatography, Liquid
MH  - *Drug Contamination
MH  - Mycotoxins/*analysis
MH  - Panax notoginseng/*chemistry
MH  - Tandem Mass Spectrometry
EDAT- 2015/05/01 06:00
MHDA- 2015/07/15 06:00
CRDT- 2015/05/01 06:00
PHST- 2015/05/01 06:00 [entrez]
PHST- 2015/05/01 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2015 Jan;50(1):81-5.