PMID- 25924722
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20150825
IS  - 1423-0003 (Electronic)
IS  - 0304-324X (Linking)
VI  - 61
IP  - 5
DP  - 2015
TI  - Association between Oxidative Stress and Frailty in an Elderly German Population: 
      Results from the ESTHER Cohort Study.
PG  - 407-15
LID - 10.1159/000380881 [doi]
AB  - BACKGROUND: Oxidative stress (OS) and inflammatory biomarkers have been 
      postulated to be important factors in the development of age-related diseases. 
      While causes of frailty are complex and multidimensional based on the interaction 
      of genetic, biological, physical, and environmental factors, the biological basis 
      of frailty has been difficult to establish. OBJECTIVE: In this study, we aimed to 
      assess the possible association between different OS and inflammatory biomarkers 
      and frailty. METHODS: This cross-sectional analysis was performed among 2,518 
      subjects participating in a large population-based cohort study on aging 
      conducted in Germany. Frailty was assessed as proposed by Fried et al. [J 
      Gerontol A Biol Sci Med Sci 2001;56:M146-M156]. OS biomarkers, biological 
      antioxidant potential (BAP), derivate of reactive oxygen metabolites (d-ROM) and 
      total thiol levels (TTL), and an established biomarker of inflammation C-reactive 
      protein (CRP) were measured by spectrophotometry and immunoturbidimetry. Logistic 
      regression models were performed to assess the relationship between the OS 
      biomarkers and frailty status. Odds ratios (OR) and 95% confidence intervals (CI) 
      were calculated to quantify the associations. RESULTS: Mean levels of d-ROM, TTL, 
      and CRP differed between frail and non-frail participants (p values <0.0001). 
      Comparing highest and lowest quartiles of the biomarkers, statistically 
      significant positive associations with frailty were observed for d-ROM (OR: 2.02, 
      95% CI: 1.25-3.25) and CRP (OR: 3.15, 95% CI: 2.00-4.96), respectively, after 
      controlling for age and sex. An inverse statistically significant association 
      with frailty was observed for TTL (OR: 0.42, 95% CI: 0.25-0.69). CONCLUSION: The 
      strong associations with OS biomarkers and CRP support a major role of OS and 
      inflammation in the development of frailty, which should be followed up in 
      further longitudinal studies on frailty.
FAU - Saum, Kai-Uwe
AU  - Saum KU
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research 
      Center (DKFZ), Heidelberg, Germany.
FAU - Dieffenbach, Aida Karina
AU  - Dieffenbach AK
FAU - Jansen, Eugene H J M
AU  - Jansen EH
FAU - Schottker, Ben
AU  - Schottker B
FAU - Holleczek, Bernd
AU  - Holleczek B
FAU - Hauer, Klaus
AU  - Hauer K
FAU - Brenner, Hermann
AU  - Brenner H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150424
PL  - Switzerland
TA  - Gerontology
JT  - Gerontology
JID - 7601655
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Sulfhydryl Compounds)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Frail Elderly
MH  - Germany
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Logistic Models
MH  - Male
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/blood
MH  - Sulfhydryl Compounds/blood
EDAT- 2015/05/01 06:00
MHDA- 2016/04/23 06:00
CRDT- 2015/05/01 06:00
PHST- 2014/12/09 00:00 [received]
PHST- 2015/02/12 00:00 [accepted]
PHST- 2015/05/01 06:00 [entrez]
PHST- 2015/05/01 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 000380881 [pii]
AID - 10.1159/000380881 [doi]
PST - ppublish
SO  - Gerontology. 2015;61(5):407-15. doi: 10.1159/000380881. Epub 2015 Apr 24.