PMID- 25925781
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20150529
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 71
IP  - 3
DP  - 2015
TI  - Decreased right hippocampal volumes and neuroprogression markers in adolescents 
      with bipolar disorder.
PG  - 140-8
LID - 10.1159/000375311 [doi]
AB  - OBJECTIVES: The aim of the present study was to assess differences and 
      correlations between the hippocampal volumes (HCVs), serum nerve growth factor 
      (NGF), and brain-derived neurotrophic factor (BDNF) levels in adolescents with 
      bipolar disorder (BP) compared to healthy controls. METHODS: Using structural 
      magnetic resonance imaging, we compared HCVs of 30 patients with euthymic BP who 
      were already enrolled in a naturalistic clinical follow-up. For comparison, we 
      enrolled 23 healthy controls between the ages of 13 and 19. The boundaries of the 
      hippocampus were outlined manually. The BDNF and NGF serum levels were measured 
      with the sandwich ELISA. RESULTS: The groups did not differ in the right or left 
      HCVs or in the NGF or BDNF serum levels. However, negative correlations were 
      found between the right HCVs and the duration of the disorder and medication and 
      positive correlations were found between the duration of the medications and the 
      NGF and BDNF levels in the patient group. Additionally, positive correlations 
      were found between the follow-up period and left normalized HCVs in both the BP 
      and lithium-treated groups. CONCLUSIONS: The right HCVs may vary with illness 
      duration and the medication used to treat BP; NGF and BDNF levels may be affected 
      by long-term usage. Further research is needed to determine whether these 
      variables and their structural correlates are associated with clinical or 
      functional differences between adolescents with BP and healthy controls.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Inal-Emiroglu, F Neslihan
AU  - Inal-Emiroglu FN
AD  - Child and Adolescent Psychiatry Department, Dokuz Eylul University Medical 
      School, Izmir, Turkey.
FAU - Resmi, Halil
AU  - Resmi H
FAU - Karabay, Nuri
AU  - Karabay N
FAU - Guleryuz, Handan
AU  - Guleryuz H
FAU - Baykara, Burak
AU  - Baykara B
FAU - Cevher, Nagihan
AU  - Cevher N
FAU - Akay, Aynur
AU  - Akay A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150425
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - G4962QA067 (Lithium Chloride)
SB  - IM
MH  - Adolescent
MH  - Antidepressive Agents/therapeutic use
MH  - Bipolar Disorder/*blood/*pathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Disease Progression
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Hippocampus/drug effects/*pathology
MH  - Humans
MH  - Lithium Chloride/therapeutic use
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Growth Factor/*blood
MH  - Statistics as Topic
MH  - Valproic Acid/therapeutic use
MH  - Young Adult
EDAT- 2015/05/01 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/05/01 06:00
PHST- 2014/09/19 00:00 [received]
PHST- 2015/01/12 00:00 [accepted]
PHST- 2015/05/01 06:00 [entrez]
PHST- 2015/05/01 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - 000375311 [pii]
AID - 10.1159/000375311 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2015;71(3):140-8. doi: 10.1159/000375311. Epub 2015 Apr 25.