PMID- 25925851
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20150529
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 71
IP  - 3
DP  - 2015
TI  - Does BDNF Val66Met Polymorphism Confer Risk for Posttraumatic Stress Disorder?
PG  - 149-53
LID - 10.1159/000381352 [doi]
AB  - BACKGROUND: Evidence has indicated that BDNF (brain-derived neurotrophic factor) 
      Val66Met genetic variant could be linked to the development of posttraumatic 
      stress disorder (PTSD). However, clinical observations studying the BDNF 
      polymorphism and the risk of PTSD yielded contradictory results. In this 
      meta-analysis we evaluated the association between BDNF Val66Met and PTSD risk. 
      METHOD: Systematic searches in online databases retrieved 6 relevant 
      publications. Different inherited models were utilized to perform the pooled 
      analysis. Subgroup analyses and sensitive analyses based on Hardy-Weinberg 
      equilibrium (HWE) test results were also carried out. RESULTS: Our study did not 
      found a significant overall effect of BDNF Val66Met on the susceptibility to PTSD 
      under various genetic models. In contrast, subgroup analyses suggested that the 
      stress status of the control group, but not ethnicity, may influence the 
      relationship of BDNF Val66Met with PTSD risk. After the exclusion of a study that 
      was not in HWE, our conclusions remained unchanged during the influence analyses. 
      CONCLUSIONS: This meta-analysis suggested no genetic association of BDNF Val66Met 
      with vulnerability to PTSD. Further research studies are warranted to clarify the 
      impact of BDNF variants on the occurrence of PTSD.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Wang, Tengfei
AU  - Wang T
AD  - Department of Pharmacology, University of Tennessee Health Science Center, 
      Memphis, Tenn., USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20150425
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Databases, Bibliographic/statistics & numerical data
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Methionine/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Stress Disorders, Post-Traumatic/*genetics
MH  - Valine/*genetics
EDAT- 2015/05/01 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/05/01 06:00
PHST- 2014/11/10 00:00 [received]
PHST- 2015/02/27 00:00 [accepted]
PHST- 2015/05/01 06:00 [entrez]
PHST- 2015/05/01 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - 000381352 [pii]
AID - 10.1159/000381352 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2015;71(3):149-53. doi: 10.1159/000381352. Epub 2015 Apr 25.