PMID- 25925967
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20150430
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 22
IP  - 4
DP  - 2015 Apr 15
TI  - [6]-gingerol dampens hepatic steatosis and inflammation in experimental 
      nonalcoholic steatohepatitis.
PG  - 452-61
LID - S0944-7113(15)00048-3 [pii]
LID - 10.1016/j.phymed.2015.01.015 [doi]
AB  - The aim of the study was to investigate the effects of [6]-gingerol 
      ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) in experimental models 
      of non-alcoholic steatohepatitis. HepG2 cells were exposed to 500 micromol/l oleic 
      acid (OA) for 24 h and preincubated for an additional 24 h with [6]-gingerol (25, 
      50 or 100 micromol/l). [6]-Gingerol (100 micromol/l) inhibited OA-induced triglyceride 
      and inflammatory marker accumulation in HepG2 cells. After being fed a high-fat 
      diet (HFD) for 2 weeks, male golden hamsters were dosed orally with [6]-gingerol 
      (25, 50 or 100 mg/kg/day) once daily for 8 weeks while maintained on HFD. 
      [6]-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and 
      reversed plasma markers of metabolic syndrome in HFD-fed hamsters. The expression 
      of inflammatory cytokine genes and nuclear transcription factor-kappaB (NF-kappaB) were 
      increased in the HFD group; these effects were attenuated by [6]-gingerol. The 
      hepatic mRNA expression of lipogenic genes such as liver X receptor-alpha, sterol 
      regulating element binding protein-1c and its target genes including acetyl-CoA 
      carboxylase, fatty acid synthase, stearoyl-CoA desaturase 1, and 
      acyl-CoA:diacylglycerol acyltransferase 2 in HFD-fed hamsters was also blocked by 
      [6]-gingerol. [6]-Gingerol may attenuate HFD-induced steatohepatitis by 
      downregulating NF-kappaB-mediated inflammatory responses and reducing hepatic 
      lipogenic gene expression.
CI  - Copyright (c) 2015 Elsevier GmbH. All rights reserved.
FAU - Tzeng, Thing-Fong
AU  - Tzeng TF
AD  - Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen 
      University, Yanpu Township, Pingtung County, Taiwan, ROC.
FAU - Liou, Shorong-Shii
AU  - Liou SS
AD  - Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen 
      University, Yanpu Township, Pingtung County, Taiwan, ROC.
FAU - Chang, Chia Ju
AU  - Chang CJ
AD  - Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen 
      University, Yanpu Township, Pingtung County, Taiwan, ROC.
FAU - Liu, I-Min
AU  - Liu IM
AD  - Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen 
      University, Yanpu Township, Pingtung County, Taiwan, ROC . Electronic address: 
      iml@tajen.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150226
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Catechols)
RN  - 0 (Cytokines)
RN  - 0 (Fatty Alcohols)
RN  - 0 (Triglycerides)
RN  - 925QK2Z900 (gingerol)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Catechols/*pharmacology
MH  - Cholesterol/metabolism
MH  - Cricetinae
MH  - Cytokines/metabolism
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Fatty Alcohols/*pharmacology
MH  - Hep G2 Cells
MH  - Humans
MH  - Inflammation/*drug therapy
MH  - Liver/drug effects/pathology
MH  - Male
MH  - Non-alcoholic Fatty Liver Disease/*drug therapy
MH  - Triglycerides/metabolism
OTO - NOTNLM
OT  - Inflammation
OT  - Lipogenesis
OT  - Nuclear transcription factor kappaB
OT  - Steatohepatitis
OT  - [6]-Gingerol
EDAT- 2015/05/01 06:00
MHDA- 2015/08/04 06:00
CRDT- 2015/05/01 06:00
PHST- 2014/07/08 00:00 [received]
PHST- 2014/12/12 00:00 [revised]
PHST- 2015/01/09 00:00 [accepted]
PHST- 2015/05/01 06:00 [entrez]
PHST- 2015/05/01 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
AID - S0944-7113(15)00048-3 [pii]
AID - 10.1016/j.phymed.2015.01.015 [doi]
PST - ppublish
SO  - Phytomedicine. 2015 Apr 15;22(4):452-61. doi: 10.1016/j.phymed.2015.01.015. Epub 
      2015 Feb 26.