PMID- 25926330
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20211203
IS  - 2157-6564 (Print)
IS  - 2157-6580 (Electronic)
IS  - 2157-6564 (Linking)
VI  - 4
IP  - 5
DP  - 2015 May
TI  - Proceedings: human leukocyte antigen haplo-homozygous induced pluripotent stem 
      cell haplobank modeled after the california population: evaluating matching in a 
      multiethnic and admixed population.
PG  - 413-8
LID - 10.5966/sctm.2015-0052 [doi]
AB  - The development of a California-based induced pluripotent stem cell (iPSC) bank 
      based on human leukocyte antigen (HLA) haplotype matching represents a 
      significant challenge and a valuable opportunity for the advancement of 
      regenerative medicine. However, previously published models of iPSC banks have 
      neither addressed the admixed nature of populations like that of California nor 
      evaluated the benefit to the population as a whole. We developed a new model for 
      evaluating an iPSC haplobank based on demographic and immunogenetic 
      characteristics reflecting California. The model evaluates haplolines or cell 
      lines from donors homozygous for a single HLA-A, HLA-B, HLA-DRB1 haplotype. We 
      generated estimates of the percentage of the population matched under various 
      combinations of haplolines derived from six ancestries (black/African American, 
      American Indian, Asian/Pacific Islander, Hispanic, and white/not Hispanic) and 
      data available from the U.S. Census Bureau, the California Institute for 
      Regenerative Medicine, and the National Marrow Donor Program. The model included 
      both cis (haplotype-level) and trans (genotype-level) matching between a modeled 
      iPSC haplobank and the recipient population following resampling simulations. We 
      showed that serving a majority (>50%) of a simulated California population 
      through cis matching would require the creation, redundant storage, and 
      maintenance of almost 207 different haplolines representing the top 60 most 
      frequent haplotypes from each ancestry group. Allowances for trans matching 
      reduced the haplobank to fewer than 141 haplolines found among the top 40 most 
      frequent haplotypes. Finally, we showed that a model optimized, custom haplobank 
      was able to serve a majority of the California population with fewer than 80 
      haplolines.
CI  - (c)AlphaMed Press.
FAU - Pappas, Derek James
AU  - Pappas DJ
AD  - Methodomics, Mortagne-sur-Sevre, France; Oakland Children's Hospital, Oakland 
      Research Institute, Oakland, California, USA;
FAU - Gourraud, Pierre-Antoine
AU  - Gourraud PA
AD  - Methodomics, Mortagne-sur-Sevre, France; Institut Sup'Biotech, Villejuif, France; 
      Department of Neurology, School of Medicine, University of California, San 
      Francisco, San Francisco, California, USA;
FAU - Le Gall, Caroline
AU  - Le Gall C
AD  - Methodomics, Mortagne-sur-Sevre, France; Institut Sup'Biotech, Villejuif, France;
FAU - Laurent, Julie
AU  - Laurent J
AD  - Methodomics, Mortagne-sur-Sevre, France; Institut Sup'Biotech, Villejuif, France;
FAU - Trounson, Alan
AU  - Trounson A
AD  - California Institute for Regenerative Medicine, San Francisco, California, USA; 
      Monash Prince Henry's Institute for Medical Research (Hudson Institute), Monash 
      Medical Centre, Melbourne, Victoria, Australia;
FAU - DeWitt, Natalie
AU  - DeWitt N
AD  - California Institute for Regenerative Medicine, San Francisco, California, USA; 
      Monash Prince Henry's Institute for Medical Research (Hudson Institute), Monash 
      Medical Centre, Melbourne, Victoria, Australia; Baxter Laboratory for Stem Cell 
      Research, Stanford University, Stanford, California, USA.
FAU - Talib, Sohel
AU  - Talib S
AD  - California Institute for Regenerative Medicine, San Francisco, California, USA;
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Stem Cells Transl Med
JT  - Stem cells translational medicine
JID - 101578022
RN  - 0 (HLA Antigens)
SB  - IM
MH  - California
MH  - Cell Line
MH  - Ethnicity/genetics
MH  - *Genetics, Population
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Histocompatibility Testing
MH  - Homozygote
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Stem Cell Research
MH  - Tissue Donors
PMC - PMC4414226
EDAT- 2015/05/01 06:00
MHDA- 2015/07/15 06:00
PMCR- 2016/05/01
CRDT- 2015/05/01 06:00
PHST- 2015/05/01 06:00 [entrez]
PHST- 2015/05/01 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - sctm.2015-0052 [pii]
AID - 20150052 [pii]
AID - 10.5966/sctm.2015-0052 [doi]
PST - ppublish
SO  - Stem Cells Transl Med. 2015 May;4(5):413-8. doi: 10.5966/sctm.2015-0052.