PMID- 25926862
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150430
LR  - 20181113
IS  - 1749-7922 (Print)
IS  - 1749-7922 (Electronic)
IS  - 1749-7922 (Linking)
VI  - 9
DP  - 2014
TI  - Increased of serum high-mobility group box chromosomal protein 1 correlated with 
      intestinal mucosal barrier injury in patients with severe acute pancreatitis.
PG  - 61
LID - 10.1186/1749-7922-9-61 [doi]
LID - 61
AB  - BACKGROUND: Secondary infections are the leading cause of death in patients with 
      severe acute pancreatitis (SAP). The gut represents the main source of pancreatic 
      contamination and related septic complications. High-mobility group box 
      chromosomal protein 1 (HMGB1) was recently identified to play an important role 
      in the SAP intestinal mucosal barrier dysfunction. OBJECTIVE: To investigate the 
      correlation of high-mobility group box 1 (HMGB1) with intestinal barrier injury 
      and infections in patients with severe acute pancreatitis (SAP). METHODS: The 
      serum levels of HMGB1, amylase, lipase, and biochemical indicators were measured 
      in 80 patients with SAP at the time of admission. Furthermore, relationship 
      between their serum HMGB1 levels and intestinal barrier injury, infection and 
      other clinical factors were analyzed. RESULTS: The mean value of serum HMGB1 
      levels was significantly higher in patients with SAP (6.02 +/- 2.42 ng/mL) than 
      that in healthy volunteers (1.87 +/- 0.63 ng/mL). Serum HMGB1 levels were 
      significantly positively correlated with the Ranson score. The HMGB1 levels were 
      higher in patients with infection during the clinical course, the HMGB1 levels in 
      non-survivors were higher than those in survivors, and positively correlated with 
      DAO activity, L/M ratio, the concentration of endotoxin (R = 0.484, P <0.01). 
      CONCLUSIONS: HMGBl level of patients with severe acute pancreatitis was 
      significantly increased, and can be used as an important indicator to determine 
      the intestinal barrier dysfunction and infection.
FAU - Xu, Gui-Fang
AU  - Xu GF
AD  - Department of Gastroenterology, Nanjing Drum tower Hospital, The Affiliated 
      Hospital of Nanjing University Medical School, Nanjing, China.
FAU - Guo, Ming
AU  - Guo M
AD  - Department of Gastroenterology, Drum Tower Clinical College of Nanjing 
      Traditional Chinese Medical University, Nanjing, China.
FAU - Tian, Zhi-Qiang
AU  - Tian ZQ
AD  - Department of General Surgery, 101st Hospital of People's Liberation Army, Wuxi, 
      China.
FAU - Wu, Guo-Zhong
AU  - Wu GZ
AD  - Department of General Surgery, 101st Hospital of People's Liberation Army, Wuxi, 
      China.
FAU - Zou, Xiao-Ping
AU  - Zou XP
AD  - Department of Gastroenterology, Nanjing Drum tower Hospital, The Affiliated 
      Hospital of Nanjing University Medical School, Nanjing, China.
FAU - Zhang, Wei-Jie
AU  - Zhang WJ
AD  - Department of Emergency, Nanjing Drum tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20141217
PL  - England
TA  - World J Emerg Surg
JT  - World journal of emergency surgery : WJES
JID - 101266603
PMC - PMC4414458
OTO - NOTNLM
OT  - High-mobility group box chromosomal protein 1 (HMGB1)
OT  - Infection
OT  - Inflammation
OT  - Injury
OT  - Intestinal mucosal barrier
OT  - Severe acute pancreatitis
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/12/17
CRDT- 2015/05/01 06:00
PHST- 2014/08/13 00:00 [received]
PHST- 2014/12/12 00:00 [accepted]
PHST- 2015/05/01 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/12/17 00:00 [pmc-release]
AID - 401 [pii]
AID - 10.1186/1749-7922-9-61 [doi]
PST - epublish
SO  - World J Emerg Surg. 2014 Dec 17;9:61. doi: 10.1186/1749-7922-9-61. eCollection 
      2014.