PMID- 25926863
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150430
LR  - 20220311
IS  - 1750-9378 (Print)
IS  - 1750-9378 (Electronic)
IS  - 1750-9378 (Linking)
VI  - 9
DP  - 2014
TI  - Detection of MMTV-Like sequences in Moroccan breast cancer cases.
PG  - 37
LID - 10.1186/1750-9378-9-37 [doi]
LID - 37
AB  - INTRODUCTION: The mouse mammary tumor virus (MMTV) like sequences have been 
      reported to be present in some human breast cancers, but their association with 
      breast cancer development is still controversial. METHODS: In this retrospective 
      study, we investigated the status of MMTV-like in 42 tumor biopsies and 18 paired 
      normal tissues from Moroccan patients with breast cancer. MMTV-like env sequences 
      were identified by PCR and confirmed by direct DNA sequencing. RESULTS: Specific 
      MMTV-like env sequences were found in 24 (57.14%) cases of breast carcinomas, and 
      6 (33.3%) cases of matched normal breast tissues. Comparison to sociologic and 
      clinicopathological parameters showed no significant association between the 
      presence of MMTV-like sequences and age, menopausal status, histological subtype, 
      histological grade, tumor size and the expression of hormone receptors (estrogen 
      ER and/or progesterone PgR) and Her 2. However, a significant correlation was 
      found between MMTV-like presence and parity (p = 0.024). CONCLUSIONS: This 
      present study confirms the presence of MMTV-like env sequences in breast cancer 
      in Moroccan women, prompting further evaluation, on large sampling, to elucidate 
      the probable causal roles of MMTV-like in breast cancer development.
FAU - Slaoui, Meriem
AU  - Slaoui M
AD  - Equipe de recherche ONCOGYMA, University of Mohamed V-Souissi, Faculty of 
      Medicine and Pharmacy of Rabat, Avenue Mohammed Belarbi El Alaoui - Souissi, BP 
      6203 Rabat, Morocco ; Unite de Biologie et Recherche Medicale, Centre National de 
      l'Energie, des Sciences et des Techniques Nucleaires, Rabat, Morocco.
FAU - El Mzibri, Mohammed
AU  - El Mzibri M
AD  - Unite de Biologie et Recherche Medicale, Centre National de l'Energie, des 
      Sciences et des Techniques Nucleaires, Rabat, Morocco.
FAU - Razine, Rachid
AU  - Razine R
AD  - Laboratory of Biostatistics, Epidemiology and Clinical Research, Universite 
      Mohamed V-Souissi Faculty of Medicine and Pharmacy of Rabat, Avenue Mohammed 
      Belarbi El Alaoui - Souissi, BP 6203 Rabat, Morocco ; Department of Public 
      Health, Universite Mohamed V-Souissi Faculty of Medicine and Pharmacy of Rabat, 
      Avenue Mohammed Belarbi El Alaoui - Souissi, BP 6203 Rabat, Morocco.
FAU - Qmichou, Zineb
AU  - Qmichou Z
AD  - Unite de Biologie et Recherche Medicale, Centre National de l'Energie, des 
      Sciences et des Techniques Nucleaires, Rabat, Morocco.
FAU - Attaleb, Mohammed
AU  - Attaleb M
AD  - Unite de Biologie et Recherche Medicale, Centre National de l'Energie, des 
      Sciences et des Techniques Nucleaires, Rabat, Morocco.
FAU - Amrani, Mariam
AU  - Amrani M
AD  - Equipe de recherche ONCOGYMA, University of Mohamed V-Souissi, Faculty of 
      Medicine and Pharmacy of Rabat, Avenue Mohammed Belarbi El Alaoui - Souissi, BP 
      6203 Rabat, Morocco.
LA  - eng
PT  - Journal Article
DEP - 20141110
PL  - England
TA  - Infect Agent Cancer
JT  - Infectious agents and cancer
JID - 101276559
PMC - PMC4414294
OTO - NOTNLM
OT  - Breast cancer
OT  - MMTV-like
OT  - Morocco
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/11/10
CRDT- 2015/05/01 06:00
PHST- 2014/07/02 00:00 [received]
PHST- 2014/10/10 00:00 [accepted]
PHST- 2015/05/01 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/11/10 00:00 [pmc-release]
AID - 522 [pii]
AID - 10.1186/1750-9378-9-37 [doi]
PST - epublish
SO  - Infect Agent Cancer. 2014 Nov 10;9:37. doi: 10.1186/1750-9378-9-37. eCollection 
      2014.