PMID- 25930743
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20150520
IS  - 1098-2264 (Electronic)
IS  - 1045-2257 (Linking)
VI  - 54
IP  - 7
DP  - 2015 Jul
TI  - Unique clonal relationship between T-cell acute lymphoblastic leukemia and 
      subsequent Langerhans cell histiocytosis with TCR rearrangement and NOTCH1 
      mutation.
PG  - 409-17
LID - 10.1002/gcc.22252 [doi]
AB  - Acute lymphoblastic leukemia (ALL) occasionally develops before or after the 
      onset of Langerhans cell histiocytosis (LCH). The mechanism of LCH developing 
      after ALL remains unclear; thus the clonality of LCH developing during 
      maintenance chemotherapy for T-cell ALL (T-ALL) was investigated. The T-ALL and 
      LCH cells tested had the same T-cell receptor (TCR) gamma rearrangement. Mutation 
      analysis of the NOTCH1 gene revealed 7213C>T (Q2405X) in exon 34 in T-ALL and LCH 
      cells, but 5156T>C (I1719T) in exon 27 only in T-ALL. Polymerase chain 
      reaction-restriction fragment length polymorphism analysis revealed three 
      patterns of NOTCH1 mutations in T-ALL cells. The results suggest that the T-ALL 
      and LCH cells were derived from a common precursor with TCR rearrangement and a 
      single NOTCH1 mutation, rather than LCH cells developing from a minor clone of 
      T-ALL with single NOTCH1 mutation.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Yokokawa, Yuichi
AU  - Yokokawa Y
AD  - Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural 
      University of Medicine Graduate School of Medical Science, Kyoto, Japan.
AD  - Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Taki, Tomohiko
AU  - Taki T
AD  - Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural 
      University of Medicine Graduate School of Medical Science, Kyoto, Japan.
FAU - Chinen, Yoshiaki
AU  - Chinen Y
AD  - Department of Molecular Hematology and Oncology, Kyoto Prefectural University of 
      Medicine Graduate School of Medical Science, Kyoto, Japan.
FAU - Kobayashi, Satoru
AU  - Kobayashi S
AD  - Department of Molecular Hematology and Oncology, Kyoto Prefectural University of 
      Medicine Graduate School of Medical Science, Kyoto, Japan.
FAU - Nagoshi, Hisao
AU  - Nagoshi H
AD  - Department of Molecular Hematology and Oncology, Kyoto Prefectural University of 
      Medicine Graduate School of Medical Science, Kyoto, Japan.
FAU - Akiyama, Masaharu
AU  - Akiyama M
AD  - Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan.
AD  - Division of Molecular Genetics, Institute of DNA Medicine, The Jikei University 
      School of Medicine, Tokyo, Japan.
FAU - Morimoto, Akira
AU  - Morimoto A
AD  - Department of Pediatrics, Jichi Medical University School of Medicine, 
      Shimotsuke, Tochigi, Japan.
FAU - Ida, Hiroyuki
AU  - Ida H
AD  - Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Taniwaki, Masafumi
AU  - Taniwaki M
AD  - Department of Molecular Hematology and Oncology, Kyoto Prefectural University of 
      Medicine Graduate School of Medical Science, Kyoto, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150430
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Antineoplastic Agents)
RN  - 0 (NOTCH1 protein, human)
RN  - 0 (Receptor, Notch1)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
SB  - IM
MH  - Antineoplastic Agents/adverse effects
MH  - Child
MH  - Clone Cells/pathology
MH  - Histiocytosis, Langerhans-Cell/drug therapy/*genetics
MH  - Humans
MH  - Langerhans Cells/pathology
MH  - Leukocytosis/genetics
MH  - Male
MH  - Mutation
MH  - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Receptor, Notch1/*genetics
MH  - Receptors, Antigen, T-Cell, gamma-delta/*genetics
MH  - T-Lymphocytes/pathology
MH  - Thrombocytopenia/genetics
EDAT- 2015/05/02 06:00
MHDA- 2016/02/03 06:00
CRDT- 2015/05/02 06:00
PHST- 2014/09/23 00:00 [received]
PHST- 2015/02/09 00:00 [accepted]
PHST- 2015/05/02 06:00 [entrez]
PHST- 2015/05/02 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
AID - 10.1002/gcc.22252 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2015 Jul;54(7):409-17. doi: 10.1002/gcc.22252. Epub 
      2015 Apr 30.