PMID- 25931267 OWN - NLM STAT- MEDLINE DCOM- 20160323 LR - 20220317 IS - 1873-5177 (Electronic) IS - 0091-3057 (Linking) VI - 134 DP - 2015 Jul TI - Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain. PG - 22-30 LID - S0091-3057(15)00127-6 [pii] LID - 10.1016/j.pbb.2015.04.010 [doi] AB - In this study, the effect of Chrysin (5,7-dihydroxyflavone), an important member of the flavonoid family, on memory impairment, oxidative stress and BDNF reduction generated by aging in mice were investigated. Young and aged mice were treated daily per 60days with Chrysin (1 and 10mg/kg; per oral, p.o.) or veichle (10ml/kg; p.o.). Mice were trained and tested in Morris Water Maze task. After the behavioural test, the levels of reactive species (RS), the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), as well as the activity of Na(+), K(+)-ATPase and the levels of brain-derived neurotrophic factor (BDNF) were determined in the prefrontal cortex (PFC) and hippocampus (HC) of mice. Results demonstrated that the age-related memory decline was partially protected by Chrysin at a dose of 1mg/kg, and normalized at the dose of 10mg/kg (p<0.001). Treatment with Chrysin significantly attenuated the increase of RS levels and the inhibition of SOD, CAT and GPx activities of aged mice. Inhibition of Na(+), K(+)-ATPase activity in PFC and HP of aged mice was also attenuated by Chrysin treatment. Moreover, Chrysin marked mitigated the decrease of BDNF levels in the PFC and HC of aged mice. These results demonstrated that flavonoid Chrysin, an antioxidant compound, was able to prevent age-associated memory probably by their free radical scavenger action and modulation of BDNF production. Thus, this study indicates that Chrysin may represent a new pharmacological approach to alleviate the age-related declines during normal age, acting as an anti-aging agent. CI - Copyright (c) 2015 Elsevier Inc. All rights reserved. FAU - Souza, Leandro Cattelan AU - Souza LC AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - Antunes, Michelle Silva AU - Antunes MS AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - Filho, Carlos Borges AU - Filho CB AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - Del Fabbro, Lucian AU - Del Fabbro L AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - de Gomes, Marcelo Gomes AU - de Gomes MG AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - Goes, Andre Tiago Rossito AU - Goes AT AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - Donato, Franciele AU - Donato F AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - Prigol, Marina AU - Prigol M AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - Boeira, Silvana Peterini AU - Boeira SP AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. FAU - Jesse, Cristiano R AU - Jesse CR AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa, Itaqui, RS, Brazil. Electronic address: cristianoricardojesse@yahoo.com.br. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150428 PL - United States TA - Pharmacol Biochem Behav JT - Pharmacology, biochemistry, and behavior JID - 0367050 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Flavonoids) RN - 3CN01F5ZJ5 (chrysin) RN - EC 1.11.1.6 (Catalase) RN - EC 1.11.1.9 (Glutathione Peroxidase) RN - EC 1.15.1.1 (Superoxide Dismutase) RN - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase) SB - IM MH - Aging/*psychology MH - Animals MH - Behavior, Animal/drug effects MH - Biomarkers/metabolism MH - Brain/*drug effects/enzymology/metabolism MH - Brain-Derived Neurotrophic Factor/*drug effects/metabolism MH - Catalase/metabolism MH - Cognition Disorders/*prevention & control MH - Flavonoids/*pharmacology MH - Glutathione Peroxidase/metabolism MH - Male MH - Mice MH - Oxidative Stress/*drug effects MH - Random Allocation MH - Sodium-Potassium-Exchanging ATPase/metabolism MH - Superoxide Dismutase/metabolism OTO - NOTNLM OT - Aging OT - Antioxidant OT - BDNF OT - Flavonoid OT - Memory EDAT- 2015/05/02 06:00 MHDA- 2016/03/24 06:00 CRDT- 2015/05/02 06:00 PHST- 2014/11/12 00:00 [received] PHST- 2015/04/05 00:00 [revised] PHST- 2015/04/20 00:00 [accepted] PHST- 2015/05/02 06:00 [entrez] PHST- 2015/05/02 06:00 [pubmed] PHST- 2016/03/24 06:00 [medline] AID - S0091-3057(15)00127-6 [pii] AID - 10.1016/j.pbb.2015.04.010 [doi] PST - ppublish SO - Pharmacol Biochem Behav. 2015 Jul;134:22-30. doi: 10.1016/j.pbb.2015.04.010. Epub 2015 Apr 28.