PMID- 25931824
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150501
LR  - 20201001
IS  - 1176-6336 (Print)
IS  - 1178-203X (Electronic)
IS  - 1176-6336 (Linking)
VI  - 11
DP  - 2015
TI  - Continual evolution of type 2 diabetes: an update on pathophysiology and emerging 
      treatment options.
PG  - 621-32
LID - 10.2147/TCRM.S67387 [doi]
AB  - Diabetes is a complex and progressive disease that has a major societal and 
      economic impact. The most common form of diabetes, type 2 diabetes mellitus 
      (T2DM), is a multifactorial disease, the pathophysiology of which involves not 
      only the pancreas but also the liver, skeletal muscle, adipose tissue, 
      gastrointestinal tract, brain, and kidney. Novel therapies with mechanisms of 
      action that are different from most existing drugs are emerging. One such class 
      consists of compounds that inhibit renal sodium-glucose cotransporter 2, which is 
      responsible for the bulk of glucose reabsorption by the kidneys. This new class 
      of compounds improves glycemic control independently of insulin and promotes 
      weight reduction, providing an additional tool to treat patients with T2DM. This 
      review discusses the underlying pathophysiology of T2DM, clinical guidelines, and 
      available and emerging treatment options, with particular emphasis on 
      sodium-glucose cotransporter 2 inhibitors.
FAU - Cornell, Susan
AU  - Cornell S
AD  - Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150416
PL  - New Zealand
TA  - Ther Clin Risk Manag
JT  - Therapeutics and clinical risk management
JID - 101253281
PMC - PMC4404882
OTO - NOTNLM
OT  - diabetes
OT  - hyperglycemia
OT  - oral antidiabetic therapies
OT  - pharmacotherapy
OT  - sodium-glucose cotransporter 2
EDAT- 2015/05/02 06:00
MHDA- 2015/05/02 06:01
PMCR- 2015/04/16
CRDT- 2015/05/02 06:00
PHST- 2015/05/02 06:00 [entrez]
PHST- 2015/05/02 06:00 [pubmed]
PHST- 2015/05/02 06:01 [medline]
PHST- 2015/04/16 00:00 [pmc-release]
AID - tcrm-11-621 [pii]
AID - 10.2147/TCRM.S67387 [doi]
PST - epublish
SO  - Ther Clin Risk Manag. 2015 Apr 16;11:621-32. doi: 10.2147/TCRM.S67387. 
      eCollection 2015.