PMID- 25933507
OWN - NLM
STAT- MEDLINE
DCOM- 20160526
LR  - 20191210
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 123
DP  - 2015 Sep
TI  - Differential effects of BDNF val(66)met in repetitive associative learning 
      paradigms.
PG  - 11-7
LID - S1074-7427(15)00073-8 [pii]
LID - 10.1016/j.nlm.2015.04.010 [doi]
AB  - In healthy young subjects, the brain derived neurotropic factor (BDNF) val(66)met 
      polymorphism negatively affects behavioural outcome in short-term motor cortex or 
      hippocampus-based learning paradigms. In repetitive training paradigms over 
      several days this effect can be overcome, in tests involving other brain areas 
      even positive effects were found. To further specify the role of this 
      polymorphism in cognitive processes, we used an associative vocabulary learning 
      paradigm over four consecutive days and tested 38 young healthy subjects and 29 
      healthy elderly subjects. As a control paradigm, we designed a nonverbal haptic 
      Braille letter-learning paradigm based on the same principles. Behavioural 
      outcome was then associated with the BDNF-genotype. In the vocabulary learning 
      task, met carrier (met/val and met/met) benefitted more from the repetitive 
      training than val/val subjects. This was paralleled by a higher reduction of 
      delayed answers during the course of the study, an effect that was also present 
      in the haptic paradigm. However, in a group of healthy elderly subjects, no 
      similar tendency was found. We conclude that the BDNF val(66)met polymorphism 
      alters highly circumscribed answer behaviours in young healthy subjects. This 
      might partly explain the high variability of previously published results.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Freundlieb, Nils
AU  - Freundlieb N
AD  - Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, 
      University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, 
      Germany.
FAU - Backhaus, Winifried
AU  - Backhaus W
AD  - Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, 
      University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, 
      Germany.
FAU - Bruggemann, Norbert
AU  - Bruggemann N
AD  - Institute of Neurogenetics, University of Lubeck, Ratzeburger Allee 160, 23562 
      Lubeck, Germany; Department of Neurology, University of Lubeck, Ratzeburger Allee 
      160, 23538 Lubeck, Germany.
FAU - Gerloff, Christian
AU  - Gerloff C
AD  - Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, 
      University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, 
      Germany.
FAU - Klein, Christine
AU  - Klein C
AD  - Institute of Neurogenetics, University of Lubeck, Ratzeburger Allee 160, 23562 
      Lubeck, Germany.
FAU - Pinnschmidt, Hans O
AU  - Pinnschmidt HO
AD  - Department of Medical Biometry and Epidemiology, University Medical Center 
      Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
FAU - Hummel, Friedhelm C
AU  - Hummel FC
AD  - Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, 
      University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, 
      Germany. Electronic address: f.hummel@uke.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150428
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Association Learning/*physiology
MH  - Auditory Perception/physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Methionine
MH  - Middle Aged
MH  - Pattern Recognition, Visual/physiology
MH  - Polymorphism, Single Nucleotide
MH  - *Practice, Psychological
MH  - Touch Perception/physiology
MH  - Valine
MH  - Vocabulary
MH  - Young Adult
OTO - NOTNLM
OT  - Associative vocabulary learning
OT  - BDNF polymorphism
OT  - Braille learning
OT  - Elderly
OT  - Gene-behaviour interaction
EDAT- 2015/05/03 06:00
MHDA- 2016/05/27 06:00
CRDT- 2015/05/03 06:00
PHST- 2014/09/16 00:00 [received]
PHST- 2015/04/20 00:00 [revised]
PHST- 2015/04/22 00:00 [accepted]
PHST- 2015/05/03 06:00 [entrez]
PHST- 2015/05/03 06:00 [pubmed]
PHST- 2016/05/27 06:00 [medline]
AID - S1074-7427(15)00073-8 [pii]
AID - 10.1016/j.nlm.2015.04.010 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2015 Sep;123:11-7. doi: 10.1016/j.nlm.2015.04.010. Epub 2015 
      Apr 28.